Perfluoropentanesulfonic acid (Synonyms: PFPeS)

Cat. No.: HY-W591838 Pureté: 97.23%: Fiche technique
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Perfluoropentanesulfonic acid (PFPeS) is a per- and polyfluoroalkyl substance. Perfluoropentanesulfonic acid increases alkaline phosphatase (ALKP). Perfluoropentanesulfonic acid induces systemic toxicity in mouse models and alters the expression of genes related to fatty acid metabolism, inflammation and skin integrity in the liver and skin.

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Perfluoropentanesulfonic acid Chemical Structure

CAS No. : 2706-91-4

Size	Stock	Quantité
Solvent
1 mg (28.56 mM * 100 μL in Ethanol)	En stock	Estimated Time of Arrival: December 31
Solvent
5 mg (28.56 mM * 500 μL in Ethanol)	En stock	Estimated Time of Arrival: December 31

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Description

In Vivo

Perfluoropentanesulfonic acid (56-225 mg/kg; topical; daily; 28 days) results in dose-dependent systemic toxicity in female B₆C₃F₁ mice, including significantly increased serum and urine PFPeS levels, up to 63% increased relative liver weight, 18% decreased relative spleen weight, altered serum chemistries, liver and skin histopathological changes, and immune cell population shifts, with greater potency observed at higher doses^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	B₆C₃F₁ mice (female, 7-8 weeks of age)^[2]
Dosage:	56 mg/kg; 113 mg/kg; 225 mg/kg
Administration:	topical; daily; 28 days
Result:	Increased serum PFPeS concentrations to 41 μg/mL (56 mg/kg), 79.8 μg/mL (113 mg/kg), 119.2 μg/mL (225 mg/kg) relative to vehicle control. Increased urine PFPeS concentrations to 220 μg/mL (56 mg/kg), 430 μg/mL (113 mg/kg), 470 μg/mL (225 mg/kg) relative to vehicle control. Increased relative liver weights by 32% (56 mg/kg), 63% (113 mg/kg), and a greater magnitude (225 mg/kg) compared to vehicle controls. Increased absolute liver weights significantly at all three doses compared to vehicle controls. Decreased relative spleen weight by 18% at the 225 mg/kg dose compared to vehicle controls. Increased serum glucose by 28% (56 mg/kg), 24% (113 mg/kg), and 25% (225 mg/kg) compared to vehicle controls. Increased serum alkaline phosphatase (ALKP) by 47% at the 225 mg/kg dose compared to vehicle controls. Induced minimal hepatocellular hypertrophy in 3/5 mice, mild hypertrophy in 1/5 mice (56 mg/kg); mild hypertrophy in all 5 mice (113 mg/kg); moderate hypertrophy in all 5 mice (225 mg/kg). Induced minimal hepatocyte necrosis in 3/5 mice (113 mg/kg) and 2/5 mice (225 mg/kg). Induced minimal epidermal hyperplasia in all 5 mice, minimal mixed cell inflammation in the dermis in 3/5 mice (225 mg/kg).

Masse moléculaire

350.11

Formule

C₅HF₁₁O₃S

CAS No.

2706-91-4

Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=S(C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)(O)=O

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureté et documentation

Purity: 97.23%

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Fiche technique (273 KB) SDS (394 KB)

COA (249 KB) HNMR (190 KB) RP-HPLC (578 KB) MS (272 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Li Y, et al. Determinants of serum half-lives for linear and branched perfluoroalkyl substances after long-term high exposure-A study in Ronneby, Sweden. Environ Int. 2022;163:107198. [Content Brief]

[2]. Cooper MP, et al. Systemic toxicity induced by topical application of the sulfonic acids, perfluorobutane sulfonic acid (PFBS) and perfluoropentane sulfonic acid (PFPeS), in a murine model. Toxicol Appl Pharmacol. 2025;503:117487.

Perfluoropentanesulfonic acid Related Classifications

Metabolic Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Perfluoropentanesulfonic acid2706-91-4PFPeSBiochemical Assay ReagentsPhosphatasehuman serumper- and polyfluoroalkyl substancemiceliver damageliverskin integrityskinmurine modelsfatty acid metabolisminflammationInhibitorinhibitorinhibit

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Perfluoropentanesulfonic acid (Synonyms: PFPeS)

Perfluoropentanesulfonic acid Related Antibodies

Recommandations en vedette

•Related Small Molecules:

•Related Proteins:

Activité biologique

Pureté et documentation

Références

Avis client

Perfluoropentanesulfonic acid Related Classifications

Calculateur de molarité

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