Phenylglyoxylic acid-d₅  (Synonyms: Benzoylformic acid-d₅)

Phenylglyoxylic acid-d₅ (Benzoylformic acid-d₅) is a deuterium labeled Phenylglyoxylic acid (HY-W010255). Phenylglyoxylic acid (Benzoylformic acid) is a metabolite of ethylbenzene and styrene (EB/S) and can be used as a biomarker of exposure to EB/S in human. Phenylglyoxylic acid can be used as drug intermediate for synthesis of antineoplastic compounds^[1][2].

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

155.16

C₈HD₅O₃

1217089-53-6

611-73-4

Solid

Off-white to light yellow

OC(C(C1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])=O)=O

Room temperature in continental US; may vary elsewhere.

Store at room temperature 3 years

• [1]. Capella KM, et al. Ethylbenzene and styrene exposure in the United States based on urinary mandelic acid and phenylglyoxylic acid: NHANES 2005-2006 and 2011-2012. Environ Res. 2019 Apr;171:101-110.  [Content Brief]

  [2]. Leont'eva L I, et al. Antiinflammatory activity of derivatives of phenylglyoxylic acid[J]. Pharmaceutical Chemistry Journal, 1993, 27(3): 195-197.

  [3]. Jiang W, et al., Diversity of complexes based on p-nitrobenzoylhydrazide, benzoylformic acid and diorganotin halides or oxides self-assemble: Cytotoxicity, the induction of apoptosis in cancer cells and DNA-binding properties. Bioorg Chem. 2020 Jan;94:103402.  [Content Brief]