2. Anti-infection PI3K/Akt/mTOR Epigenetics
  3. Bacterial AMPK
  4. Pinocembrin chalcone

Pinocembrin chalcone  (Synonyms: 2',4',6'-Trihydroxychalcone)

Cat. No.: HY-N7515 Purity: 98.74%
COA
SDS
Handling Instructions Technical Support

Pinocembrin chalcone (2',4',6'-Trihydroxychalcone) is an antibacterial compound from Helichrysum Trilineatum. Pinocembrin chalcone facilitates AMP-activated protein kinase (AMPK) activation, improves glucose tolerance, increases muscle FAO and reduces fat accumulation in the liver and skeletal muscles in high-fat diet-induced (HFD) diabetic mice. Pinocembrin chalcone is promising for research of gastric ulcers and diabetes.

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Pinocembrin chalcone

Pinocembrin chalcone 화학구조

CAS No. : 4197-97-1

사이즈 가격 재고 수량
1 mg 해외재고보유
5 mg 해외재고보유
10 mg   견적 받기  
50 mg   견적 받기  

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Other Forms of Pinocembrin chalcone:

Pinocembrin chalcone Related Antibodies

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1 BRSK1 BRSK2 HUNK AMPKα

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

Pinocembrin chalcone (2',4',6'-Trihydroxychalcone) is an antibacterial compound from Helichrysum Trilineatum. Pinocembrin chalcone facilitates AMP-activated protein kinase (AMPK) activation, improves glucose tolerance, increases muscle FAO and reduces fat accumulation in the liver and skeletal muscles in high-fat diet-induced (HFD) diabetic mice. Pinocembrin chalcone is promising for research of gastric ulcers and diabetes[1][2].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
25.4 μM
Compound: 8c
Inhibition of human SGLT1 expressed in HEK293 cells assessed as reduction in 2-deoxyglucose uptake pretreated for 10 mins followed by 2-deoxyglucose addition in presence of sodium buffer measured after 1 hr by resazurin dye based fluorescence assay
Inhibition of human SGLT1 expressed in HEK293 cells assessed as reduction in 2-deoxyglucose uptake pretreated for 10 mins followed by 2-deoxyglucose addition in presence of sodium buffer measured after 1 hr by resazurin dye based fluorescence assay
[PMID: 28098449]
HEK293 IC50
33.3 μM
Compound: 8c
Inhibition of human SGLT2 expressed in HEK293 cells assessed as reduction in 2-deoxyglucose uptake pretreated for 10 mins followed by 2-deoxyglucose addition in presence of sodium buffer measured after 1 hr by resazurin dye based fluorescence assay
Inhibition of human SGLT2 expressed in HEK293 cells assessed as reduction in 2-deoxyglucose uptake pretreated for 10 mins followed by 2-deoxyglucose addition in presence of sodium buffer measured after 1 hr by resazurin dye based fluorescence assay
[PMID: 28098449]
RBL-1 IC50
140 μM
Compound: 3
Inhibition of 5-lipoxygenase in rat RBL1 cells
Inhibition of 5-lipoxygenase in rat RBL1 cells
10.1007/s00044-013-0745-7
RBL-1 IC50
140 μM
Compound: 3
Inhibition of cyclooxygenase in rat RBL1 cells
Inhibition of cyclooxygenase in rat RBL1 cells
10.1007/s00044-013-0745-7
RBL-1 IC50
140 μM
Compound: 4
In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined
In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined
[PMID: 8254620]
In Vitro

Pinocembrin chalcone (1.0 μg) is active at inhibiting the growth of S. aureus.[1].
Pinocembrin chalcone (10 μM, 24 h) markedly increases fatty acid oxidation rate and increases the phosphorylation of AMPKα with no cytotoxicity in C2C12 myotubes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pinocembrin chalcone Related Antibodies

Western Blot Analysis[2]

Cell Line: C2C12 myotubes
Concentration: 10 μM
Incubation Time: 24 h
Result: Stimulated AMPK phosphorylation at much lower concentrations (1 μM) within 2 h in C2C12 myotubes.
In Vivo

Pinocembrin chalcone (30 mg/kg, oral gavage, daily for 3 weeks) improves glucose tolerance and fat accumulation through fatty acid oxidation rate increase in skeletal muscle, which is mainly mediated by AMPK activation in HFD-induced diabetic mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HFD-induced diabetic mice[2]
Dosage: 30 mg/kg
Administration: oral gavage, daily for 3 weeks
Result: Reduced the circulating FFA levels and fat accumulation in the liver and muscles by increasing FAO, which improved glucose tolerance in HFD-induced diabetic mice.
분자량

256.25

화학식

C15H12O4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=C(O)C=C(O)C=C1O)/C=C/C2=CC=CC=C2
Structure Classification
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

순도&문서

Purity: 98.74%

SDS (393 KB)

COA (247 KB) HNMR (85 KB) RP-HPLC (235 KB)

Handling Instructions (2659 KB)
References
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Pinocembrin chalcone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pinocembrin chalcone4197-97-12',4',6'-TrihydroxychalconeBacterialAMPKAMP-activated protein kinaseantibacterial compoundglucose toleranceFAOfat accumulationhigh-fat diet-induced diabetic micegastric ulcersdiabetesInhibitorinhibitorinhibit

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상품명:
Pinocembrin chalcone
Cat. No.:
HY-N7515
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