2. 天然物
  3. Disease Research Fields Plants Flavonoids Phenols
  4. Leguminosae Chalcones Polyphenols
  5. Cajanus cajan (L.) Millsp.
  6. Pinostrobin chalcone

Pinostrobin chalcone  (Synonyms: ピノストロビンカルコン)

製品番号: HY-N3057 純度: 99.94%
COA 取扱説明書 Technical Support

Pinostrobin chalcone is found to be potent natural cytotoxic compounds against MDA-MB-231 and HT-29 colon cancer cell lines(IC50 = 20.42±2.23 and 22.51±0.42 μg/mL).

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Pinostrobin chalcone

Pinostrobin chalcone 構造式

CAS 番号 : 18956-15-5

容量 価格（税別） 在庫状況 数量
1 mg $100 在庫あり
5 mg $290 在庫あり
10 mg $460 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

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Other Forms of Pinostrobin chalcone:

Pinostrobin chalcone 関連抗体

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製品説明

Pinostrobin chalcone is found to be potent natural cytotoxic compounds against MDA-MB-231 and HT-29 colon cancer cell lines(IC50 = 20.42±2.23 and 22.51±0.42 μg/mL)[1].

Cellular Effect
Cell Line Type Value Description References
MCF7 IC50
>60 3
Compound: 2g
The compound was tested for antiproliferative activity against MCF-7 human breast cancer cells
The compound was tested for antiproliferative activity against MCF-7 human breast cancer cells
[PMID: 11720850]
J774.A1 IC50
42.76 3
Compound: 138
Anti-inflammatory activity against mouse J774.A1 cells assessed as inhibition of LPS-induced IL-1beta mRNA expression level pretreated for 30 mins followed by LPS-induction and measured after 6 hrs by RT-PCR analysis
Anti-inflammatory activity against mouse J774.A1 cells assessed as inhibition of LPS-induced IL-1beta mRNA expression level pretreated for 30 mins followed by LPS-induction and measured after 6 hrs by RT-PCR analysis
[PMID: 37683361]
MCF7 IC50
> 60 3
Compound: 2g
The compound was tested for antiproliferative activity against MCF-7 human breast cancer cells
The compound was tested for antiproliferative activity against MCF-7 human breast cancer cells
[PMID: 11720850]
RAW264.7 IC50
43.07 3
Compound: 138
Anti-inflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-1beta mRNA expression level pretreated for 30 mins followed by LPS-induction and measured after 6 hrs by RT-PCR analysis
Anti-inflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-1beta mRNA expression level pretreated for 30 mins followed by LPS-induction and measured after 6 hrs by RT-PCR analysis
[PMID: 37683361]
分子量

270.28

分子式

C16H14O4
CAS 番号
Appearance

Solid

Color

Orange to red

SMILES

O=C(C1=C(C=C(OC)C=C1O)O)/C=C/C2=CC=CC=C2
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (369.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6999 mL 18.4993 mL 36.9987 mL
5 mM 0.7400 mL 3.6999 mL 7.3997 mL
10 mM 0.3700 mL 1.8499 mL 3.6999 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (9.25 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション

純度: 99.94%

COA (247 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6999 mL 18.4993 mL 36.9987 mL 92.4967 mL
5 mM 0.7400 mL 3.6999 mL 7.3997 mL 18.4993 mL
10 mM 0.3700 mL 1.8499 mL 3.6999 mL 9.2497 mL
15 mM 0.2467 mL 1.2333 mL 2.4666 mL 6.1664 mL
20 mM 0.1850 mL 0.9250 mL 1.8499 mL 4.6248 mL
25 mM 0.1480 mL 0.7400 mL 1.4799 mL 3.6999 mL
30 mM 0.1233 mL 0.6166 mL 1.2333 mL 3.0832 mL
40 mM 0.0925 mL 0.4625 mL 0.9250 mL 2.3124 mL
50 mM 0.0740 mL 0.3700 mL 0.7400 mL 1.8499 mL
60 mM 0.0617 mL 0.3083 mL 0.6166 mL 1.5416 mL
80 mM 0.0462 mL 0.2312 mL 0.4625 mL 1.1562 mL
100 mM 0.0370 mL 0.1850 mL 0.3700 mL 0.9250 mL
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Pinostrobin chalcone Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pinostrobin chalcone18956-15-5OthersInhibitorinhibitorinhibit

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製品名:
Pinostrobin chalcone
製品番号:
HY-N3057
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