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  6. Polygalacturonic acid

Polygalacturonic acid  (Synonyms: Galacturonic acid polymer)

Art. -Nr.: HY-N6613 Reinheit: 99.58%
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Polygalacturonic acid (Galacturonic acid polymer) is transparent colloid, is a major component of the cell wall. Polygalacturonic acid can be used to prepare silver nanoparticles (AgNPs), as an antioxidant and anti-inflammatory that protect cells from destructive effect of elevated ROS and accelerate wound healing. Polygalacturonic acid nanoparticles also displays anti-bacterial activity.

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Polygalacturonic acid

Polygalacturonic acid Chemische Struktur

CAS. Nr. : 25990-10-7

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Polygalacturonic acid Related Antibodies

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Beschreibung

Polygalacturonic acid (Galacturonic acid polymer) is transparent colloid, is a major component of the cell wall. Polygalacturonic acid can be used to prepare silver nanoparticles (AgNPs), as an antioxidant and anti-inflammatory that protect cells from destructive effect of elevated ROS and accelerate wound healing. Polygalacturonic acid nanoparticles also displays anti-bacterial activity[1][2].

In Vitro

Polygalacturonic acid can be used to format a durable hydrogel, to prolong the effect of drugs. Polygalacturonic acid hydrogel/hyaluronate, conjugated Ibuprofen.html" class="link-product" target="_blank">Ibuprofen (HY-78131) for example, prevents epidural fibrosis, the severe scar tissue adhesion of laminectomized male adult rats, and increases the efficiency of local inflammation control and reduces the side-effect of Ibuprofen.html" class="link-product" target="_blank">Ibuprofen[1].
Polygalacturonic acid hydrogel/hyaluronate (PGA-HA) (2%, 200 μL; 24 h) shows low cytotoxicity on L929 fibroblasts[1].
Polygalacturonic acid (PGA) preparing (Ag-PGA/HA)-PVA nanoparticles, shows anti-bacterial activity against gram-positive bacterial strains; Bacillus Subtilis and Staphylococcus Aureus, as well as gram-negative bacterial strain; Escherichia Coli[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Polygalacturonic acid Related Antibodies
In Vivo

Polygalacturonic acid (external application; 14 d) enhances a quick healing of wound infection in albino rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Full thickness wound model in albino rats (60-day-old, 180 g)[2]
Dosage: Ag-Polygalacturonic acid/hyaluronic acid nanoparticles
Administration: Applied on dorsal muscle fascia; cleaned the wound daily with alcohol; for 14 days
Result: Resulted no sign of abscess formation or hypertrophic scars both in the early phase; 5th day or in the final phase; 14th day, respectively.
Showed significant wound healing from day 8 while treated with (Ag-PGA/HA)-PVA nanofiber and blank (PGA/HA)-PVA nanofiber and induced epithelization on day 14.
Formel

(C6H10O7)x
CAS. Nr.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(O)=O.[x]
Structure Classification
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit
In Vitro: 

0.1 M NaOH : 10 mg/mL (ultrasonic and warming and adjust pH to 11 with NaOH and heat to 60°C)

H2O : < 0.1 mg/mL (insoluble)

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Reinheit & Dokumentation

Purity: 99.58%

SDS (394 KB)

COA (246 KB) RP-HPLC (233 KB)

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Polygalacturonic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Polygalacturonic acid25990-10-7Galacturonic acid polymerOthersantibacterialhyaluronic acidnanofiberpolygalacturonic acidsilver nanoparticleswound dressingepidural fibrosisibuprofeninjectable hydrogelprostaglandin E2Inhibitorinhibitorinhibit

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