2. Protein Tyrosine Kinase/RTK
  3. Bcr-Abl
  4. PPY-A

PPY-A is a potent T315I mutant and wild-type Abl kinases inhibitor with IC50s of 9 and 20 nM, respectively. PPY-A inhibits Ba?F3 cells transformed with wild-type Abl and Abl T315I mutantl with IC50s of 390 and 180 nM, respectively. PPY-A can be used for the research of chronic myeloid leukemia (CML).

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PPY-A

PPY-A 構造式

CAS 番号 : 875634-01-8

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 313 在庫あり
Solution
10 mM * 1 mL in DMSO USD 313 在庫あり
Solid
1 mg $114 在庫あり
5 mg $285 在庫あり
10 mg $430 在庫あり
25 mg $710 在庫あり
50 mg $957 在庫あり
100 mg $1284 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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PPY-A 関連抗体

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製品説明

PPY-A is a potent T315I mutant and wild-type Abl kinases inhibitor with IC50s of 9 and 20 nM, respectively. PPY-A inhibits Ba?F3 cells transformed with wild-type Abl and Abl T315I mutantl with IC50s of 390 and 180 nM, respectively. PPY-A can be used for the research of chronic myeloid leukemia (CML)[1].

分子量

372.42

分子式

C22H20N4O2
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC(C2=CN=C(NC=C3C4=CC=CC=C4OC)C3=C2)=CN=C1)N(C)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 50 mg/mL (134.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6851 mL 13.4257 mL 26.8514 mL
5 mM 0.5370 mL 2.6851 mL 5.3703 mL
10 mM 0.2685 mL 1.3426 mL 2.6851 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6851 mL 13.4257 mL 26.8514 mL 67.1285 mL
5 mM 0.5370 mL 2.6851 mL 5.3703 mL 13.4257 mL
10 mM 0.2685 mL 1.3426 mL 2.6851 mL 6.7129 mL
15 mM 0.1790 mL 0.8950 mL 1.7901 mL 4.4752 mL
20 mM 0.1343 mL 0.6713 mL 1.3426 mL 3.3564 mL
25 mM 0.1074 mL 0.5370 mL 1.0741 mL 2.6851 mL
30 mM 0.0895 mL 0.4475 mL 0.8950 mL 2.2376 mL
40 mM 0.0671 mL 0.3356 mL 0.6713 mL 1.6782 mL
50 mM 0.0537 mL 0.2685 mL 0.5370 mL 1.3426 mL
60 mM 0.0448 mL 0.2238 mL 0.4475 mL 1.1188 mL
80 mM 0.0336 mL 0.1678 mL 0.3356 mL 0.8391 mL
100 mM 0.0269 mL 0.1343 mL 0.2685 mL 0.6713 mL
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PPY-A Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PPY-A875634-01-8Bcr-AblT315I mutantwild-type Abl kinases inhibitorBa F3 cellschronic myeloid leukemiaCMLInhibitorinhibitorinhibit

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製品名:
PPY-A
製品番号:
HY-12083
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