875634-01-8
Chemical Structure
PPY-A
- CAS No.: 875634-01-8
- Formula:C22H20N4O2
- Molecular Weight:372.42
IUPAC Name: 5-(3-(2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-N,N-dimethylnicotinamide
InChIKey: GYQRHHQPEMOLKH-UHFFFAOYSA-N
SMILES: O=C(C1=CC(C2=CN=C(NC=C3C4=CC=CC=C4OC)C3=C2)=CN=C1)N(C)C
Biological Activity: PPY-A is a potent T315I mutant and wild-type Abl kinases inhibitor with IC50s of 9 and 20 nM, respectively. PPY-A inhibits Ba?F3 cells transformed with wild-type Abl and Abl T315I mutantl with IC50s of 390 and 180 nM, respectively. PPY-A can be used for the research of chronic myeloid leukemia (CML)[1].
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PPY-A | 98.02% | PPY-A is a potent T315I mutant and wild-type Abl kinases inhibitor with IC50s of 9 and 20 nM, respectively. PPY-A inhibits Ba?F3 cells transformed with wild-type Abl and Abl T315I mutantl with IC50s of 390 and 180 nM, respectively. PPY-A can be used for the research of chronic myeloid leukemia (CML). | ||||||||||||||||||||
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Keywords
