PROTAC AKR1C3 degrader-1 

PROTAC AKR1C3 degrader-1 (compound 5) is a potent AKR1C3 PROTAC degrader. PROTAC AKR1C3 degrader-1 decreases the protein expression of AKR1C3, AKR1C1/2, and ARv7. PROTAC AKR1C3 degrader-1 has the potential for the research of prostate cancer. (Blue:ubiquitin E3 ligase cereblon ligand (HY-A0003), Black: linker (HY-163647); Pink: AKR1C3 inhibitor (HY-163610))^[1].

PROTAC AKR1C3 degrader-1 (compound 5) (10 nM; 0-72 h) decreases the protein level of AKR1C3, AKR1C1/2, and ARv7 in a time-dependent manner^[1].
PROTAC AKR1C3 degrader-1 (0.001, 0.01, 0.1, 1 µM; 72 h) inhibits 22Rv1 cell growth in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

841.86

C₄₅H₄₃N₇O₁₀

O=C(/C=C/C1=CC(C2=CC=CC=C2)=CC(C(NCC3=CC=C(C=C3)OCC4=CN(N=N4)CCOCCOCC(NC5=CC=CC6=C5CN(C6=O)C7CCC(NC7=O)=O)=O)=O)=C1)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Carmona AV, et al. Discovery of an Aldo-Keto reductase 1C3 (AKR1C3) degrader. Commun Chem. 2024 Apr 29;7(1):95.  [Content Brief]