2. PROTAC
  3. Ligands for E3 Ligase Molecular Glues
  4. PT-179

PT-179 is an orthogonal Thalidomide (HY-14658) derivative that targets cereblon without causing off-target degradation effects. PT-179 is able to specifically bind CRBN, form a ternary complex with a target protein fused to a zinc finger (ZF) degron, and mediate the degradation of the tagged protein. For example, PT-179 binds to the ubiquitin ligase substrate receptor cereblon by forming a complex with SD40 and efficiently degrades proteins N- or C-terminally fused to SD40 or SD36 (DC50 for eGFP: 4.5 nM and 14.3 nM). PT-179 can be used to develop compact protein degradation tagging platforms.

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PT-179

PT-179 構造式

CAS 番号 : 2924858-25-1

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 165 在庫あり
Solution
10 mM * 1 mL in DMSO USD 165 在庫あり
Solid
5 mg $150 在庫あり
10 mg $250 在庫あり
25 mg $450 在庫あり
50 mg $650 在庫あり
100 mg $920 在庫あり
500 mg $1830 在庫あり
1 g $2580 在庫あり
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* アイテムを追加する前、数量をご選択ください

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PT-179 関連抗体

Top Publications Citing Use of Products

Ligands for E3 Ligase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B KLHL41

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  • 純度とドキュメンテーション

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製品説明

PT-179 is an orthogonal Thalidomide (HY-14658) derivative that targets cereblon without causing off-target degradation effects. PT-179 is able to specifically bind CRBN, form a ternary complex with a target protein fused to a zinc finger (ZF) degron, and mediate the degradation of the tagged protein. For example, PT-179 binds to the ubiquitin ligase substrate receptor cereblon by forming a complex with SD40 and efficiently degrades proteins N- or C-terminally fused to SD40 or SD36 (DC50 for eGFP: 4.5 nM and 14.3 nM). PT-179 can be used to develop compact protein degradation tagging platforms[1].

IC50 & Target

Cereblon

 

体外実験

SD40 is a degradation tag specific for PT-179. PT-179 (1-10 μM; 24 h) can induce eGFP degradation in HEK293T cells. The higher the evolution degree of the degron variant, the stronger the degradation efficiency of the corresponding tagged protein[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PT-179 関連抗体
分子量

343.33

分子式

C17H17N3O5
CAS 番号
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C2=CC=C(N3CCOCC3)C=C2C(N1C4C(NC(CC4)=O)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 125 mg/mL (364.08 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9126 mL 14.5632 mL 29.1265 mL
5 mM 0.5825 mL 2.9126 mL 5.8253 mL
10 mM 0.2913 mL 1.4563 mL 2.9126 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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In Vivo Dissolution Calculator
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純度とドキュメンテーション

純度: 99.91%

COA (248 KB) HNMR (259 KB) LCMS (93 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9126 mL 14.5632 mL 29.1265 mL 72.8162 mL
5 mM 0.5825 mL 2.9126 mL 5.8253 mL 14.5632 mL
10 mM 0.2913 mL 1.4563 mL 2.9126 mL 7.2816 mL
15 mM 0.1942 mL 0.9709 mL 1.9418 mL 4.8544 mL
20 mM 0.1456 mL 0.7282 mL 1.4563 mL 3.6408 mL
25 mM 0.1165 mL 0.5825 mL 1.1651 mL 2.9126 mL
30 mM 0.0971 mL 0.4854 mL 0.9709 mL 2.4272 mL
40 mM 0.0728 mL 0.3641 mL 0.7282 mL 1.8204 mL
50 mM 0.0583 mL 0.2913 mL 0.5825 mL 1.4563 mL
60 mM 0.0485 mL 0.2427 mL 0.4854 mL 1.2136 mL
80 mM 0.0364 mL 0.1820 mL 0.3641 mL 0.9102 mL
100 mM 0.0291 mL 0.1456 mL 0.2913 mL 0.7282 mL
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PT-179 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PT-1792924858-25-1PT179PT 179Ligands for E3 LigaseMolecular GluesE3 ligase-recruiting MoietyMolecular glue complexzinc finger proteincompact proteindegradation tagInhibitorinhibitorinhibit

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製品名:
PT-179
製品番号:
HY-160695
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