Pyridine-3-sulfonic acid (Synonyms: Pyridine-3-sulphonic acid)

Art. -Nr.: HY-W015467 Reinheit: 98.0%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Pyridine-3-sulfonic acid (Pyridine-3-sulphonic acid) is an orally active structural analog of Nicotine acid (HY-B0143). Pyridine-3-sulfonic acid significantly reduces hepatic cholesterol synthesis in rats but lacks cholesterol-lowering activity. Pyridine-3-sulfonic acid does not interfere with the metabolism of Nicotine acid.

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Pyridine-3-sulfonic acid Chemische Struktur

CAS. Nr. : 636-73-7

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10 mM * 1 mL in DMSO ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Auf Lager	Estimated Time of Arrival: December 31
Solid
25 g	Auf Lager	Estimated Time of Arrival: December 31
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Beschreibung

In Vivo

Pyridine-3-sulfonic acid (1%, 1 g/100 g daily diet, p.o. with food, for 21 days) significantly reduces liver cholesterol synthesis in rats^[1].
Pyridine-3-sulfonic acid (0.5-2 g, p.o. with food) does not interfere with the binding or metabolism of nicotinamide to coenzyme I/II in normal dogs or dogs deficient in Niacin^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Normal diet and high cholesterol diet model established in male Wistar rats (150-160 g)^[1]
Dosage:	1%, 1 g/100 g daily diet
Administration:	Oral administration (p.o.) with food, for 21 days
Result:	Did not significantly alter serum cholesterol levels in the normal diet group. Did not show cholesterol-lowering activity in the high-cholesterol diet group. Significantly reduced liver cholesterol synthesis.

Molekulargewicht

159.17

Formel

C₅H₅NO₃S

CAS. Nr.

636-73-7

Appearance

Solid

Color

White to off-white

SMILES

O=S(O)(C1=CC=CN=C1)=O

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 25 mg/mL (157.06 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.2826 mL	31.4130 mL	62.8259 mL
5 mM	1.2565 mL	6.2826 mL	12.5652 mL
10 mM	0.6283 mL	3.1413 mL	6.2826 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (15.71 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (15.71 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (15.71 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Reinheit & Dokumentation

Purity: 98.0%

Select Batch:

Data Sheet (277 KB) SDS (476 KB)

COA (254 KB) HNMR (118 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Kritchevsky D, Tepper SA. INFLUENCE OF NICOTINIC, PICOLINIC AND PYRIDINE-3-SULFONIC ACIDS ON CHOLESTEROL METABOLISM IN THE RAT. J Nutr. 1964 Jan;82(1):157-61. [Content Brief]

[2]. Gaebler OH, Beher WT. STUDIES OF ANTIMETABOLITES: I. PYRIDINE-3-SULFONIC ACID AND 3-ACETYLPYRIDINE. Journal of Biological Chemistry. 1951 Jan 1;188(1):343-9.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.2826 mL	31.4130 mL	62.8259 mL	157.0648 mL
	5 mM	1.2565 mL	6.2826 mL	12.5652 mL	31.4130 mL
	10 mM	0.6283 mL	3.1413 mL	6.2826 mL	15.7065 mL
	15 mM	0.4188 mL	2.0942 mL	4.1884 mL	10.4710 mL
	20 mM	0.3141 mL	1.5706 mL	3.1413 mL	7.8532 mL
	25 mM	0.2513 mL	1.2565 mL	2.5130 mL	6.2826 mL
	30 mM	0.2094 mL	1.0471 mL	2.0942 mL	5.2355 mL
	40 mM	0.1571 mL	0.7853 mL	1.5706 mL	3.9266 mL
	50 mM	0.1257 mL	0.6283 mL	1.2565 mL	3.1413 mL
	60 mM	0.1047 mL	0.5235 mL	1.0471 mL	2.6177 mL
	80 mM	0.0785 mL	0.3927 mL	0.7853 mL	1.9633 mL
	100 mM	0.0628 mL	0.3141 mL	0.6283 mL	1.5706 mL

Pyridine-3-sulfonic acid Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pyridine-3-sulfonic acid636-73-7Pyridine-3-sulphonic acidDrug DerivativeDrug derivativeNicotinic acidWistar ratsAntimetabolitesHypocholesterolemic effectInhibitorinhibitorinhibit

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Pyridine-3-sulfonic acid (Synonyms: Pyridine-3-sulphonic acid)

Pyridine-3-sulfonic acid Related Antibodies

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

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Biologische Aktivität

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