2. Anticuerpos inhibidores
  3. Biosimilar Antibodies
  4. Monoclonal Antibodies
  5. Racotumomab

Racotumomab  (Synonyms: 1E10)

Cat. No.: HY-P99254 Pureza: ≥99.0%
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Racotumomab (Anti-Human NGcGM3 Recombinant Antibody) is an anti-idiotype monoclonal antibody (MAb). Racotumomab reacts to Neu-glycolyl (NeuGc)-containing gangliosides, sulfatides, and other antigens expressed in tumors. Racotumomab is an active anticancer agent for lung cancer.

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No. CAS : 946832-34-4

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Racotumomab Related Antibodies

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Descripciòn

Racotumomab (Anti-Human NGcGM3 Recombinant Antibody) is an anti-idiotype monoclonal antibody (MAb). Racotumomab reacts to Neu-glycolyl (NeuGc)-containing gangliosides, sulfatides, and other antigens expressed in tumors. Racotumomab is an active anticancer agent for lung cancer[1][2][3].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

GM3
In Vitro

Racotumomab induces a specific humoral and cellular immune response against the NeuGcGM3 ganglioside present in tumor cells, stimulating the cell death[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Racotumomab Related Antibodies
In Vivo

Racotumomab (50 μg/dose, i.p.) together with Keyhole limpet hemocyanin (KLH) inhibits tumor growth in F3II cell (s.c.) mammary tumor mice model[2].
Racotumomab (50 μg/dose, s.c.) together with Pemetrexed (100 mg/kg) is highly effective against lung nodules in 3LL cell (s.c.) mice xenograft[3].
Racotumomab (50-200 μg/dose, s.c.) shows no significant antitumor effect in 3LL cell (s.c.) mice xenograft[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 3LL cell (s.c.) mice xenograft[3]
Dosage: 50 μg/dose, together with Pemetrexed (100 mg/kg)
Administration: Subcutaneous injection (s.c.)
Result: Reduced lung nodules.
Ensayo clínico
Gene ID

8869  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Peso molecular

145.5 kDa

No. CAS
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Racotumomab]
Envío

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • IgG1-kappa
Pureza y Documentación
Referencias
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Racotumomab Related Classifications

  • Calculadora de molaridad

  • Calculadora de dilución

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Racotumomab946832-34-41E10OthersTumorNSCLClung canceranti-metastaticNeuGcGM33LL cellF3II cellInhibitorinhibitorinhibit

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Nombre del producto:
Racotumomab
Cat. No.:
HY-P99254
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