Ruzinurad (Synonyms: HR011303; SHR4640)

Name: Ruzinurad
Brand: MedChemExpress
SKU: HY-W052011
Rating: 4.5 (0 reviews)

Cat. No.: HY-W052011 Purity: 99.26%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Ruzinurad (HR011303) is a highly selective URATl inhibitor (WO2020088641, compound I). Ruzinurad can be used in the study of hyperuricemia.

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Ruzinurad 화학구조

CAS No. : 1638327-48-6

사이즈	재고	수량

무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
500 mg	해외재고보유	Estimated Time of Arrival: December 31
1 g	견적 받기
5 g	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

Ruzinurad (HR011303) is a highly selective URATl inhibitor (WO2020088641, compound I). Ruzinurad can be used in the study of hyperuricemia^[1].

IC₅₀ & Target

URAT1^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	33.7 nM Compound: 41	Inhibition of human URAT1 expressed in HEK293 cells assessed as [14C]uric acid uptake after 12 mins by scintillation counter Inhibition of human URAT1 expressed in HEK293 cells assessed as [14C]uric acid uptake after 12 mins by scintillation counter	[PMID: 26704267]

In Vitro

Ruzinurad is a highly selective URATl inhibitor^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

분자량

338.22

화학식

C₁₄H₁₂BrNO₂S

CAS No.

1638327-48-6

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1(SC2=CC=NC3=CC=C(Br)C=C23)CCC1)O

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 33.33 mg/mL (98.55 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9567 mL	14.7833 mL	29.5666 mL
5 mM	0.5913 mL	2.9567 mL	5.9133 mL
10 mM	0.2957 mL	1.4783 mL	2.9567 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 1 mg/mL (2.96 mM); Clear solution

This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

순도&문서

Purity: 99.26%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (253 KB) RP-HPLC (247 KB)

Handling Instructions (2659 KB)

References

[1]. WO2020088641

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9567 mL	14.7833 mL	29.5666 mL	73.9164 mL
	5 mM	0.5913 mL	2.9567 mL	5.9133 mL	14.7833 mL
	10 mM	0.2957 mL	1.4783 mL	2.9567 mL	7.3916 mL
	15 mM	0.1971 mL	0.9856 mL	1.9711 mL	4.9278 mL
	20 mM	0.1478 mL	0.7392 mL	1.4783 mL	3.6958 mL
	25 mM	0.1183 mL	0.5913 mL	1.1827 mL	2.9567 mL
	30 mM	0.0986 mL	0.4928 mL	0.9856 mL	2.4639 mL
	40 mM	0.0739 mL	0.3696 mL	0.7392 mL	1.8479 mL
	50 mM	0.0591 mL	0.2957 mL	0.5913 mL	1.4783 mL
	60 mM	0.0493 mL	0.2464 mL	0.4928 mL	1.2319 mL
	80 mM	0.0370 mL	0.1848 mL	0.3696 mL	0.9240 mL

Ruzinurad Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ruzinurad1638327-48-6HR011303 SHR4640HR 011303HR-011303SHR4640SHR 4640SHR-4640URAT1Urate transporter 1SLC22A12Inhibitorinhibitorinhibit

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Ruzinurad (Synonyms: HR011303; SHR4640)

고객리뷰

Ruzinurad Related Antibodies

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•Related Small Molecules:

•Related Proteins:

Biological Activity

순도&문서

References

고객리뷰

Ruzinurad Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

Ruzinurad Related Classifications

Keywords:

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SAFETY DATA SHEET (SDS)

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