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8-oxoguanine

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA Glycosylase (2) Endogenous Metabolite (2) Glycosyltransferase (1)
By Research Areas:	Cancer (2) Infection (1) Inflammation/Immunology (3) Metabolic Disease (2) Neurological Disease (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113338

8-Hydroxyguanine 8-oxoguanine; 8-oxo-Gua	Endogenous Metabolite	Metabolic Disease
8-Hydroxyguanine is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. 8-Hydroxyguanine induces mutagenesis and leads to a transversion from G to T. 8-Hydroxyguanine is a marker of DNA oxidative damage .

HY-139056

SU0268 3 Publications Verification	Glycosyltransferase	Infection Inflammation/Immunology Cancer
SU0268 is a potent and specific inhibitor of 8-Oxoguanine DNA glycosylase 1 (OGG1). SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection .

HY-112902

OGG1-IN-08 2 Publications Verification	DNA Glycosylase	Inflammation/Immunology
OGG1-IN-08 is a potent 8-oxoguanine DNA glycosylase-1 (OGG1) inhibitor with an IC₅₀ value of 0.22 μM. OGG1-IN-08 decreases both the glycosylase and lyase activities of OGG1 .

HY-179014

OGG1 activator-1	DNA Glycosylase	Neurological Disease Inflammation/Immunology Cancer
OGG1 activator-1 (Compound 30) is a selective 8-oxoguanine DNA glycosylase-1 (OGG1) activator with an AC₅₀ value of 0.58 μM. OGG1 activator-1 does not activate nor inhibit the key downstream repair enzyme APE1, and shows > 150-fold selectivity for the activation effect on OGG1. OGG1 activator-1 exhibits extremely high metabolic stability and almost no cytotoxicity. OGG1 activator-1 can be used for the study of oxidative stress-related diseases (such as neurodegenerative diseases, fibrotic diseases, cancer, inflammation, etc.) .

HY-113338A

8-Hydroxyguanine hydrochloride 8-oxoguanine hydrochloride; 8-oxo-Gua hydrochloride	Endogenous Metabolite	Metabolic Disease
8-Hydroxyguanine hydrochloride is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. 8-Hydroxyguanine hydrochloride induces mutagenesis and leads to a transversion from G to T. 8-Hydroxyguanine hydrochloride is a marker of DNA oxidative damage .

8-Hydroxyguanine 8-oxoguanine; 8-oxo-Gua	Natural Products Immune System Disorder Classification of Application Fields Disease markers Other Diseases Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
8-Hydroxyguanine is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. 8-Hydroxyguanine induces mutagenesis and leads to a transversion from G to T. 8-Hydroxyguanine is a marker of DNA oxidative damage .

Species:	Human (3) E.coli (1)
Tag:	SUMO (1) His (3) Tag Free (1)
Source:	E. coli (4)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P72338

	OGG1 Protein, Human (His) 1 Publications Verification 8-oxoguanine DNA glycosylase; 8-hydroxyguanine DNA glycosylase; MMH; MUTM; OGH1	Human	E. coli
	The OGG1 protein is a DNA repair enzyme specifically designed to cleave DNA at the 8-oxoG residue and plays a key role in maintaining genome integrity. It demonstrates the ability to excise damaged bases such as 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine from the DNA structure (FAPY). OGG1 Protein, Human (His) is the recombinant human-derived OGG1 protein, expressed by E. coli , with C-6*His labeled tag.

HY-P72338A

	OGG1 Protein, Human (N-His) 8-oxoguanine DNA glycosylase; 8-hydroxyguanine DNA glycosylase; MMH; MUTM; OGH1	Human	E. coli
	The OGG1 protein is a DNA repair enzyme specifically designed to cleave DNA at the 8-oxoG residue and plays a key role in maintaining genome integrity.It demonstrates the ability to excise damaged bases such as 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine from the DNA structure (FAPY).OGG1 Protein, Human (N-His) is the recombinant human-derived OGG1 protein, expressed by E.coli , with N-6*His labeled tag.

HY-P70968

	OGG1 Protein, Human 1 Publications Verification N-Glycosylase/DNA Lyase; 8-oxoguanine DNA Glycosylase; DNA-(Apurinic or Apyrimidinic Site) Lyase; AP Lyase; OGG1; MMH; MUTM; OGH1	Human	E. coli
	The OGG1 protein is a DNA repair enzyme specifically designed to cleave DNA at the 8-oxoG residue and plays a key role in maintaining genome integrity. It demonstrates the ability to excise damaged bases such as 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine from the DNA structure (FAPY). OGG1 Protein, Human (GST) is the recombinant human-derived OGG1 protein, expressed by E. coli , with tag free.

HY-P71482

	MutT Protein, E.coli (His-SUMO) mutT; b0099; JW0097; 8-oxo-dGTP diphosphatase; 8-oxo-dGTPase; EC 3.6.1.55; 7,8-dihydro-8-oxoguanine-triphosphatase; Mutator protein MutT; dGTP pyrophosphohydrolase	E.coli	E. coli
	The MutT protein maintains the genome by hydrolyzing 8-oxo-deoxyguanosine triphosphate (8-oxo-dGTP) and 8-oxo-guanosine triphosphate (8-oxo-GTP) to their corresponding monophosphates. Integrity plays a key role. This prevents misincorporation of 8-oxoGua into DNA and RNA, ensuring the fidelity of the nucleotide library. MutT Protein, E.coli (His-SUMO) is the recombinant E. coli-derived MutT protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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8-oxoguanine

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