8-Hydroxyguanine hydrochloride
8-Hydroxyguanine hydrochloride is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. 8-Hydroxyguanine hydrochloride induces mutagenesis and leads to a transversion from G to T. 8-Hydroxyguanine hydrochloride is a marker of DNA oxidative damage.
For research use only. We do not sell to patients.
- CAS No.: 1246818-54-1
- Formula: C5H6ClN5O2
- Molecular Weight:203.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
The most common product of ROS-induced base damage is 8-Hydroxyguanine. Failure to promptly remove 8-Hydroxyguanine often causes mutations during DNA replication. 8-Hydroxyguanine is cleared from cells by the 8-oxoG DNA glycosylase 1 (OGG1)-mediated oxidative damage base excision repair pathway so as to prevent cells from suffering dysfunction due to oxidative stress[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1246818-54-1
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Molecular Weight 203.59
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Formula C5H6ClN5O2
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SMILES
O=C1NC(NC(N)=N2)=C(N1)C2=O.Cl
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Synonyms
8-Oxoguanine hydrochloride; 8-oxo-Gua hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Spencer JP, et al., DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cells. FEBS Lett. 1995 Oct 30;374(2):233-6. [Content Brief]
[2]. Zhang W, et al. Effect of 8-Hydroxyguanine DNA Glycosylase 1 on the Function of Immune Cells. Antioxidants (Basel). 2023 Jun 19;12(6):1300. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
8-Hydroxyguanine hydrochloride Related Classifications
HY-113338A Related Classifications
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