AE | MedChemExpress (MCE) Life Science Reagents

By Targets:	5-HT Receptor (2) Akt (1) Apoptosis (1) Calcium Channel (1) Elastase (1) Epigenetic Reader Domain (1) HDAC (2) mAChR (1) MicroRNA (4) NO Synthase (1) Parasite (1) PI3K (1) Potassium Channel (1) Prostaglandin Receptor (2) Sodium Channel (1) TGF-beta/Smad (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (3) Endocrinology (1) Infection (2) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (4)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19406

AE-3763

Elastase Cardiovascular Disease Inflammation/Immunology

AE-3763 is a peptide-based human neutrophil elastase inhibitor with an IC₅₀ of 29 nM.

AE-3763	Elastase	Cardiovascular Disease Inflammation/Immunology
AE-3763 is a peptide-based human neutrophil elastase inhibitor with an IC₅₀ of 29 nM.

HY-131929

AE-ITU dihydrobromide	NO Synthase	Inflammation/Immunology
AE-ITU dihydrobromide is the dihydrobromide form of AE-ITU. AE-ITU dihydrobromide is a selective inhibitor for inducible NO synthase (iNOS), and attenuates the liver dysfunction caused by endotoxaemia in rats .

HY-50901

ONO-AE3-208 5+ Cited Publications AE 3-208	Prostaglandin Receptor	Endocrinology Cancer
ONO-AE3-208 is a selective and orally active EP4 receptor antagonist with a K_i of 1.3 nM. ONO-AE3-208 shows less potently affects EP3, FP, and TP receptors (K_i of 30 nM, 790 nM, and 2400 nM, respectively). ONO-AE3-208 suppresses cell invasion, migration, and metastasis of prostate cancer .

HY-P99359

Elezanumab ABT-555; AE12-1Y-QL; Anti-RGMA Reference Antibody (elezanumab)	TGF-beta/Smad	Metabolic Disease
Elezanumab (ABT-555; AE12-1Y-QL) is a human monoclonal antibody that selectively targets repulsive guidance molecule A (RGMa). Elezanumab potently inhibited RGMa mediated BMP signalling via the SMAD1/5/8 pathway, with an IC₅₀ around 97 pM. Elezanumab promotes neuroregeneration and neuroprotection in neuronal injury and demyelination models binds N-terminal RGMa, blocks BMP signaling and lacks RGMc cross-reactivity. elezanumab has neuroregenerative and neuroprotective activities without impact on iron metabolism .

HY-U00284

AE0047 Hydrochloride

Calcium Channel Cardiovascular Disease

AE0047 Hydrochloride is a calcium blocker, used in the research of hypertensive disease.

AE0047 Hydrochloride	Calcium Channel	Cardiovascular Disease
AE0047 Hydrochloride is a calcium blocker, used in the research of hypertensive disease.

HY-138831

AES-350	HDAC Apoptosis	Cancer
AES-350 is a potent and orally active HDAC6 inhibitor with an IC₅₀ and a K_i of 0.0244 μM and 0.035 μM, respectively. AES-350 is also against HDAC3, HDAC8 in an enzymatic activity assay with IC₅₀ values of 0.187 μM and 0.245 μM, respectively. AES-350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research .

HY-114483

AES-135 1 Publications Verification	HDAC	Cancer
AES-135, a hydroxamic acid-based pan-HDAC inhibitor, prolongs survival in an orthotopic mouse model of pancreatic cancer. AES-135 inhibits HDAC3, HDAC6, HDAC8, and HDAC11 with IC₅₀s ranging from 190-1100 nM .

HY-133910

Lu AE98134	Sodium Channel	Neurological Disease
Lu AE98134, an activator of voltage-gated sodium channels, acts as a partly selective Na_v1.1 channels positive modulator. Lu AE98134 also increases the activity of Na_v1.2 and Na_v1.5 channels but not of Na_v1.4, Na_v1.6 and Na_v1.7 channels. Lu AE98134 can be used to analyze pathophysiological functions of the Na_v1.1 channel in various central nervous system diseases, including cognitive restoring in schizophrenia, et al .

HY-R01638

hsa-miR-548ae-3p mimic	MicroRNA	Cancer
hsa-miR-548ae-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-548ae-3p mimic hsa-miR-548ae-3p mimic

HY-N12273

Soyasaponin Ae

Acetyl-soyasaponin A5
Others Others

Soyasaponin Ae (Acetyl-soyasaponin A5) can be isolated from the seeds of Glycine max MERRILL .
HY-W042301

Xipamide

Others Cardiovascular Disease

Xipamide is a sulfonamide-based diuretic. Xipamide is an antihypertensive agent able to selectively inhibit the anion exchanger (AE) .

Soyasaponin Ae Acetyl-soyasaponin A5	Others	Others
Soyasaponin Ae (Acetyl-soyasaponin A5) can be isolated from the seeds of Glycine max MERRILL .

Xipamide	Others	Cardiovascular Disease
Xipamide is a sulfonamide-based diuretic. Xipamide is an antihypertensive agent able to selectively inhibit the anion exchanger (AE) .

HY-RI01638

hsa-miR-548ae-3p inhibitor	MicroRNA
hsa-miR-548ae-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-548ae-3p inhibitor hsa-miR-548ae-3p inhibitor

HY-14338A

Idalopirdine hydrochloride Lu AE58054 hydrochloride	5-HT Receptor	Neurological Disease
Idalopirdine hydrochloride (Lu AE58054 hydrochloride) is a potent, selective 5-HT6 receptor antagonist with a K_i value of 0.83 nM. Idalopirdine hydrochloride may be used in studies of Alzheimer's disease and schizophrenia, among other related disorders .

HY-14338

Idalopirdine Lu AE58054	5-HT Receptor	Neurological Disease
Idalopirdine (Lu AE58054 ) is a potent, selective 5-HT6 receptor antagonist with a K_i value of 0.83 nM. Idalopirdine may be used in studies of Alzheimer's disease and schizophrenia, among other related disorders .

HY-R01638A

hsa-miR-548ae-3p agomir	MicroRNA
hsa-miR-548ae-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-548ae-3p agomir hsa-miR-548ae-3p agomir

HY-114974

Rivenprost ONO-4819; ONO-AE1-734	Prostaglandin Receptor	Others Inflammation/Immunology
Rivenprost (ONO-4819; ONO-AE1-734) is a selective agonist for prostaglandin E receptor EP4 with K_i of 0.7 nM. Rivenprost exhibits hepatoprotective and bone anabolic effects .

HY-RI01638A

hsa-miR-548ae-3p antagomir	MicroRNA
hsa-miR-548ae-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-548ae-3p antagomir hsa-miR-548ae-3p antagomir

HY-120004

PF-06827443	mAChR	Infection
PF-06827443 is a potent, low-clearance, orally bioavailable, and CNS-penetrant M1-selective positive allosteric modulator (PAM) with minimal agonist activity. PF-06827443 induce cholinergic AEs and convulsion .

HY-151527

PI3K/Akt/CREB activator 1	Akt PI3K Epigenetic Reader Domain	Neurological Disease
PI3K/Akt/CREB activator 1 (compound AE-18) is a potent, orally active PI3K/Akt/CREB activator. PI3K/Akt/CREB activator 1 promotes neuronal proliferation, induced differentiation of Neuro-2a cells into a neuron-like morphology, and accelerated the establishment of axon-dendrite polarization of primary hippocampal neurons through upregulating brain-derived neurotrophic factor via the PI3K/Akt/CREB pathway. PI3K/Akt/CREB activator 1 can be used in research of vascular dementia (VaD) .

HY-118607

VU041	Potassium Channel Parasite	Infection
VU041 is a first submicromolar-affinity inhibitor of *Anopheles (An.) gambiae* and Aedes (Ae.) aegypti inward rectifier potassium 1 (Kir1) channels with IC₅₀ values of 2.5 μM and 1.7 μM, respectively. VU041 inhibits appreciably is mammalian Kir2.1 (IC₅₀ of 12.7 μM), and has less inhibitory effect on mammalian Kir1.1, Kir4.1, Kir6.2/SUR1, and Kir7.1. VU041 also induces impaired Malpighian tubule function .

Cat. No.	Product Name	Target	Research Area

HY-P5018

NOTA-AE105	Peptides	Cancer
NOTA-AE105 is an PET ligand of urokinase-type plasminogen activator receptor (uPAR), which can be radiolabeled by ⁶⁴Cu and ⁶⁸Ga. ⁶⁸Ga-NOTA-AE105 and ⁶⁴Cu-NOTA-AE105 shows high image contrast, resulting in clear tumor delineation .

Cat. No.	Product Name	Target	Research Area

HY-P99359

Elezanumab ABT-555; AE12-1Y-QL; Anti-RGMA Reference Antibody (elezanumab)	TGF-beta/Smad	Metabolic Disease
Elezanumab (ABT-555; AE12-1Y-QL) is a human monoclonal antibody that selectively targets repulsive guidance molecule A (RGMa). Elezanumab potently inhibited RGMa mediated BMP signalling via the SMAD1/5/8 pathway, with an IC₅₀ around 97 pM. Elezanumab promotes neuroregeneration and neuroprotection in neuronal injury and demyelination models binds N-terminal RGMa, blocks BMP signaling and lacks RGMc cross-reactivity. elezanumab has neuroregenerative and neuroprotective activities without impact on iron metabolism .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N12273

Soyasaponin Ae Acetyl-soyasaponin A5	Structural Classification Polysaccharides Leguminosae Glycine max (L.) merr Source classification Plants Saccharides	Others
Soyasaponin Ae (Acetyl-soyasaponin A5) can be isolated from the seeds of Glycine max MERRILL .

Cat. No.	Compare	Product Name	Species	Source

HY-P71566

	AE-binding protein 1/Aebp1 Protein, Mouse (His-SUMO) AEbp1; Aclp; Adipocyte enhancer-binding protein 1; AE-binding protein 1; Aortic carboxypeptidase-like protein	Mouse	E. coli
	AE-binding protein 1/Aebp1 Protein, Mouse (His-SUMO) plays a critical role in regulating adipogenesis, and the proinflammation process in macrophages, including macrophage cholesterol homeostasis, foam cell formation and the development of atherosclerosis.


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HY-P82074

Band 3 Antibody (YA1819)

AE1; BND3; CD233; DI; EMPB3; EPB3; FR; RTA1A; SLC4A1; SW; WD; WD1; WR
WB, IHC-P, ICC/IF Human

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
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