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CCL3

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By Targets:	CCR (1) Fungal (1) LPL Receptor (1) PGE synthase (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (2) Endocrinology (1) Infection (1) Inflammation/Immunology (4) Neurological Disease (1)

6

Inhibitors & Agonists

2

Natural
Products

9

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Bindarit 10+ Cited Publications AF2838	CCR	Neurological Disease Inflammation/Immunology Endocrinology Cancer
Bindarit (AF2838) is a selective inhibitor of the monocyte chemotactic proteins *MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, and no effect on other CC and CXC chemokines such as MIP-1α/CCL3, MIP-1β/CCL4, MIP-3/CCL*23. Bindarit also has anti-inflammatory activity .

UT-11	PGE synthase	Inflammation/Immunology
UT-11 is a potent and brain-permeable microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with IC₅₀s of 0.10 μM and 2.00 μM for inhibiting PGE₂ production in human (SK-N-AS) and murine (BV2) cells, respectively .

CCL3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CCL3 Human Pre-designed siRNA Set A contains three designed siRNAs for CCL3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CCL3 Human Pre-designed siRNA Set A CCL3 Human Pre-designed siRNA Set A

CCL3L3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CCL3L3 Human Pre-designed siRNA Set A contains three designed siRNAs for CCL3L3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CCL3L3 Human Pre-designed siRNA Set A CCL3L3 Human Pre-designed siRNA Set A

IMMH001	LPL Receptor	Inflammation/Immunology
IMMH001, also called SYL930, is an orally active, potent and selective S1P1 (sphingosine-1-phosphate receptor 1) agonist. IMMH001 decreased levels of both chemokines and proinflammatory cytokines, including IL-1β, IL-5, IL-18, IP10, CCL3, and CCL5. IMMH001 can be used for rheumatoid arthritis (RA) research .

HY-W505771

Seselin

Fungal Infection Inflammation/Immunology Cancer

Seselin is an anticancer, antinociceptive, anti-inflammatory and antifungal agent. Seselin is orally active ^[3].

Species:	Human (5) Mouse (3) Rat (1)
Tag:	His (4) Tag Free (5)
Source:	HEK293 (2) CHO (1) E. coli (6)

Cat. No.	Compare	Product Name	Species	Source

	*MIP-1 alpha/CCL3* Protein, Mouse (His)** rMuCCL3, His; C-C motif chemokine 3; Heparin-binding chemotaxis protein; LD78 alpha; MIP-1 alpha; SCYA3; CCL3	Mouse	E. coli
	MIP-1 alpha/CCL3 Protein, Mouse (His), an important chemokine, is a key regulator of immune microenvironment and primarily mediates the trafficking of immune cells in both inflammation and cancer. MIP-1 alpha/CCL3 Protein, Mouse (His) is a recombinant mouse CCL3 (A24-A92) expressed by E.coil with a His tag.

	CCL3 Protein, Rat CCL3; Mip1a; Scya3; C-C motif chemokine 3; Macrophage inflammatory protein 1-alpha; MIP-1-alpha; Small-inducible cytokine A3	Rat	E. coli
	The CCL3 protein is a single factor with inflammatory and chemotactic properties that attracts immune cells such as monocytes, neutrophils, eosinophils, basophils, and lymphocytes. It is critical in pulmonary TNF-α production, neutrophil recruitment, and lung injury and may serve as an autocrine mediator of TNF-α production by macrophages. CCL3 Protein, Rat is the recombinant rat-derived CCL3 protein, expressed by E. coli , with tag free. The total length of CCL3 Protein, Rat is 69 a.a., with molecular weight of ~7.9-10 kDa.

	*MIP-1 alpha/CCL3* Protein, Human** rHuMIP-1α/CCL3; C-C motif chemokine 3; MIP1A; SCYA3	Human	E. coli
	MIP-1 alpha/CCL3 Protein, Human, an important chemokine, is a key regulator of immune microenvironment and primarily mediates the trafficking of immune cells in both inflammation and cancer. MIP-1 alpha/CCL3 Protein, Human is a recombinant human CCL3 (A23-A92) expressed by E.coil.

	*MIP-1 alpha/CCL3* Protein, Human (CHO)** rHuMIP-1α/CCL3; C-C motif chemokine 3; MIP1A; SCYA3	Human	CHO
	MIP-1 alpha/CCL3 Protein, Human (CHO), an important chemokine, is a key regulator of immune microenvironment and primarily mediates the trafficking of immune cells in both inflammation and cancer. MIP-1 alpha/CCL3 Protein, Human (CHO) is a recombinant human CCL3 (A27-A92) expressed by CHO.

	*LD78-beta/CCL3L1 Protein, Human (HEK293 His)* rHuCCL3L1, His; C-C Motif Chemokine 3-Like 1; Small-Inducible Cytokine A3-Like 1; Tonsillar Lymphocyte LD78 Beta Protein; CCL3L1; D17S1718; G0S19-2; SCYA3L1; CCL3L3	Human	HEK293
	LD78-beta/CCL3L1 Protein, Human (HEK293 His) is a multiallelic copy number variable, which plays a crucial role in immunoregulatory and hosts defense through the production of macrophage inflammatory protein (MIP)-1α.

	*MIP-1 alpha/CCL3* Protein, Mouse (HEK293)** 2 Publications Verification rMuMIP-1α/CCL3; C-C motif chemokine 3; MIP1A; SCYA3	Mouse	HEK293
	MIP-1 alpha/CCL3 Protein, Mouse (HEK293), an important chemokine, is a key regulator of immune microenvironment and primarily mediates the trafficking of immune cells in both inflammation and cancer. MIP-1 alpha/CCL3 Protein, Mouse (HEK293) is a recombinant mouse CCL3 (A24-A92) expressed by HEK293.

	*LD78-beta/CCL3L1 Protein, Human* rHuLD78β/CCL3L1; C-C motif chemokine 3-like 1; SCYA3L1	Human	E. coli
	LD78-beta/CCL3L1 Protein, Human is a potent ligand for the HIV-1 co-receptor CCR5, which is essential for viral entry into human host cells.

	*Animal-Free MIP-1 alpha/CCL3* Protein, Human (His)** MIP-1a: Macrophage Inflammatory Protein-1α; LD78α	Human	E. coli
	MIP-1 alpha/CCL3 protein, a monokine with inflammatory and chemokinetic properties, binds to CCR1, CCR4, and CCR5 receptors. Produced by CD8+ T-cells, it inhibits various strains of HIV-1, HIV-2, and SIV in a dose-dependent manner. Additionally, MIP-1 alpha/CCL3 self-associates and forms a heterodimer with MIP-1-beta(3-69). Animal-Free MIP-1 alpha/CCL3 Protein, Human (His) is the recombinant human-derived animal-FreeMIP-1 alpha/CCL3 protein, expressed by E. coli , with N-His. The total length of Animal-Free MIP-1 alpha/CCL3 Protein, Human (His) is 66 a.a., with molecular weight of ~7.43 kDa.

	*Animal-Free MIP-1 alpha/CCL3* Protein, Mouse (His)** MIP-1a: Macrophage Inflammatory Protein-1α; LD78α	Mouse	E. coli
	MIP-1 alpha/CCL3 protein, a monokine, displays inflammatory, pyrogenic, and chemokinetic properties. It induces potent chemotaxis in eosinophils and activates calcium release in neutrophils via high-affinity receptor binding. Animal-Free MIP-1 alpha/CCL3 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeMIP-1 alpha/CCL3 protein, expressed by E. coli , with N-His, N-His labeled tag. The total length of Animal-Free MIP-1 alpha/CCL3 Protein, Mouse (His) is 69 a.a., with molecular weight of ~8.69 kDa.

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