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Gallocyanine chloride, a synthetic blue dyestuff, blocks DKK1 inhibitory activity by disrupting DKK1/LRP6 interaction. Its association with LRP6 is weak (IC50 of about 3 μM in the inhibition of DKK1 binding). Gallocyanine dye acts as a potential agent for the research of Alzheimer's disease and related neurodegenerative tauopathies [1].
WAY-262611 is a wingless β-Catenin agonist that increases bone formation rate with an EC50 of 0.63 μM in TCF-Luciferase assay. WAY-262611 is also a Dkk1 inhibitor.
Mirodenafil (SK3530) dihydrochloride is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. Mirodenafil dihydrochloride is a glucocorticoid receptor (GR) modulator Mirodenafil dihydrochloride activates the Wnt/β-catenin signaling pathway by downregulating Dkk1 expression. Mirodenafil dihydrochloride can be used for the research of erectile dysfunction (ED), Alzheimer’s disease (AD) and systemic sclerosis (SSc) [1] .
Mirodenafil (SK3530) is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. Mirodenafil is a glucocorticoid receptor (GR) modulator Mirodenafil activates the Wnt/β-catenin signaling pathway by downregulating Dkk1 expression. Mirodenafil can be used for the research of erectile dysfunction (ED), Alzheimer’s disease (AD) and systemic sclerosis (SSc) [1] .
DKK1 Human Pre-designed siRNA Set A contains three designed siRNAs for DKK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
DKK1 protein antagonizes canonical Wnt signaling by inhibiting LRP5/6-Wnt interaction and forming a ternary complex with KREMEN, thereby promoting LRP5/6 internalization. In addition to its Wnt-dependent role, DKK1 has Wnt-independent anti-apoptotic activity by inhibiting the pro-apoptotic function of KREMEN1. DKK1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived DKK1 protein, expressed by HEK293 , with C-His labeled tag. The total length of DKK1 Protein, Mouse (HEK293, His) is 241 a.a., with molecular weight of ~38.29 kDa.
DKK-1 Proteinas are potent antagonists of canonical Wnt signaling, inhibiting LRP5/6-Wnt interactions and forming a ternary complex with KREMEN to promote LRP5/6 internalization. In addition to its proapoptotic function by antagonizing KREMEN1 independently of Wnt, DKK-1 also exhibits antiapoptotic activity. DKK-1 Protein, Human (HEK293, Fc) is the recombinant human-derived DKK-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of DKK-1 Protein, Human (HEK293, Fc) is 235 a.a., with molecular weight of ~60-80 kDa.
DKK-1 Proteinas are potent antagonists of canonical Wnt signaling, inhibiting LRP5/6-Wnt interactions and forming a ternary complex with KREMEN to promote LRP5/6 internalization. In addition to its proapoptotic function by antagonizing KREMEN1 independently of Wnt, DKK-1 also exhibits antiapoptotic activity. DKK-1 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived DKK-1 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of DKK-1 Protein, Rhesus Macaque (N256Q, HEK293, Fc) is 266 a.a., with molecular weight of 60-70 kDa.
DKK-1 Proteinas are potent antagonists of canonical Wnt signaling, inhibiting LRP5/6-Wnt interactions and forming a ternary complex with KREMEN to promote LRP5/6 internalization. In addition to its proapoptotic function by antagonizing KREMEN1 independently of Wnt, DKK-1 also exhibits antiapoptotic activity. DKK1 Protein, Human (HEK293, His) is the recombinant human-derived DKK1 protein, expressed by HEK293 , with C-His labeled tag. The total length of DKK1 Protein, Human (HEK293, His) is 235 a.a., with molecular weight of ~42.9 kDa.
DKK-1 Proteinas are potent antagonists of canonical Wnt signaling, inhibiting LRP5/6-Wnt interactions and forming a ternary complex with KREMEN to promote LRP5/6 internalization. In addition to its proapoptotic function by antagonizing KREMEN1 independently of Wnt, DKK-1 also exhibits antiapoptotic activity. DKK-1 Protein, Rhesus Macaque (N256Q, HEK293, His) is the recombinant Rhesus Macaque-derived DKK-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of DKK-1 Protein, Rhesus Macaque (N256Q, HEK293, His) is 266 a.a., with molecular weight of 38-43 kDa.
DKK-1 Protein, with co-receptor and lipoprotein receptor binding activities, crucially regulates ossification and neuron death positively. Primarily located in the extracellular space, DKK-1 is implicated in anodontia, showing biased expression in kidney (RPKM 4.7), brain (RPKM 0.6), and two other tissues. Its role in the WNT signaling pathway and impact on visual epilepsy highlight its significance in developmental and neurological contexts. DKK-1 Protein, Rat (HEK293, His) is the recombinant rat-derived DKK-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of DKK-1 Protein, Rat (HEK293, His) is 239 a.a., with molecular weight of ~27.4 kDa.
DKK-1 Proteinas, a potent antagonist of canonical Wnt signaling, inhibits LRP5/6-Wnt interaction and forms a ternary complex with KREMEN, facilitating LRP5/6 internalization. Beyond antagonizing KREMEN1's pro-apoptotic function independently of Wnt, DKK-1 exhibits anti-apoptotic activity. Implicated in limb development, it modulates Wnt signaling for normal limb patterning. Interacting with LRP5/6 through its C-terminal Cys-rich domain, DKK-1 attenuates Wnt-mediated signaling influenced by MESD and/or KREMEN, emphasizing its multifaceted role in regulating cellular processes. DKK1 Protein, Human (HEK293, His-Avi) is the recombinant human-derived DKK1 protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of DKK1 Protein, Human (HEK293, His-Avi) is 235 a.a., with molecular weight of 45-55 kDa.
DKK-1 Proteinas are potent antagonists of canonical Wnt signaling, inhibiting LRP5/6-Wnt interactions and forming a ternary complex with KREMEN to promote LRP5/6 internalization. In addition to its proapoptotic function by antagonizing KREMEN1 independently of Wnt, DKK-1 also exhibits antiapoptotic activity. DKK-1 Protein, Human (235a.a, HEK293, His) is the recombinant human-derived DKK-1 protein, expressed by HEK293 , with N-8*His labeled tag. The total length of DKK-1 Protein, Human (235a.a, HEK293, His) is 235 a.a., with molecular weight of 42-47 kDa.
DKK-1 Proteinas, a potent antagonist of canonical Wnt signaling, inhibits LRP5/6-Wnt interaction and forms a ternary complex with KREMEN, facilitating LRP5/6 internalization. Beyond antagonizing KREMEN1's pro-apoptotic function independently of Wnt, DKK-1 exhibits anti-apoptotic activity. Implicated in limb development, it modulates Wnt signaling for normal limb patterning. Interacting with LRP5/6 through its C-terminal Cys-rich domain, DKK-1 attenuates Wnt-mediated signaling influenced by MESD and/or KREMEN, emphasizing its multifaceted role in regulating cellular processes. DKK1 Protein, Human (89a.a, HEK293, mFc) is the recombinant human-derived DKK1 protein, expressed by HEK293, with C-mFc labeled tag. The total length of DKK1 Protein, Human (89a.a, HEK293, mFc) is 89 a.a., with molecular weight of 45-53 kDa.
DKK-1 Proteinas, a potent antagonist of canonical Wnt signaling, inhibits LRP5/6-Wnt interaction and forms a ternary complex with KREMEN, facilitating LRP5/6 internalization. Beyond antagonizing KREMEN1's pro-apoptotic function independently of Wnt, DKK-1 exhibits anti-apoptotic activity. Implicated in limb development, it modulates Wnt signaling for normal limb patterning. Interacting with LRP5/6 through its C-terminal Cys-rich domain, DKK-1 attenuates Wnt-mediated signaling influenced by MESD and/or KREMEN, emphasizing its multifaceted role in regulating cellular processes. DKK-1 C terminal Domain Protein, Human (HEK293, Fc-Avi) is the recombinant human-derived DKK-1 C terminal Domain protein, expressed by HEK293, with C-Avi, C-hFc labeled tag. The total length of DKK-1 C terminal Domain Protein, Human (HEK293, Fc-Avi) is 89 a.a., with molecular weight of 45-55 kDa.
DKK-1 Proteinas, a potent antagonist of canonical Wnt signaling, inhibits LRP5/6-Wnt interaction and forms a ternary complex with KREMEN, facilitating LRP5/6 internalization. Beyond antagonizing KREMEN1's pro-apoptotic function independently of Wnt, DKK-1 exhibits anti-apoptotic activity. Implicated in limb development, it modulates Wnt signaling for normal limb patterning. Interacting with LRP5/6 through its C-terminal Cys-rich domain, DKK-1 attenuates Wnt-mediated signaling influenced by MESD and/or KREMEN, emphasizing its multifaceted role in regulating cellular processes. DKK-1 N terminal Domain Protein, Human (HEK293, Fc-Avi) is the recombinant human-derived DKK-1 N terminal Domain protein, expressed by HEK293, with C-Avi, C-hFc labeled tag. The total length of DKK-1 N terminal Domain Protein, Human (HEK293, Fc-Avi) is 111 a.a., with molecular weight of 50-60 kDa.
DKK-1 Proteinas, a potent antagonist of canonical Wnt signaling, inhibits LRP5/6-Wnt interaction and forms a ternary complex with KREMEN, facilitating LRP5/6 internalization. Beyond antagonizing KREMEN1's pro-apoptotic function independently of Wnt, DKK-1 exhibits anti-apoptotic activity. Implicated in limb development, it modulates Wnt signaling for normal limb patterning. Interacting with LRP5/6 through its C-terminal Cys-rich domain, DKK-1 attenuates Wnt-mediated signaling influenced by MESD and/or KREMEN, emphasizing its multifaceted role in regulating cellular processes. DKK-1 C terminal Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived DKK-1 C terminal protein, expressed by HEK293, with C-Avi, C-hFc labeled tag. The total length of DKK-1 C terminal Protein, Human (Biotinylated, HEK293, Fc-Avi) is 89 a.a., with molecular weight of 50-55 kDa.
DKK-1 Proteinas, a potent antagonist of canonical Wnt signaling, inhibits LRP5/6-Wnt interaction and forms a ternary complex with KREMEN, facilitating LRP5/6 internalization. Beyond antagonizing KREMEN1's pro-apoptotic function independently of Wnt, DKK-1 exhibits anti-apoptotic activity. Implicated in limb development, it modulates Wnt signaling for normal limb patterning. Interacting with LRP5/6 through its C-terminal Cys-rich domain, DKK-1 attenuates Wnt-mediated signaling influenced by MESD and/or KREMEN, emphasizing its multifaceted role in regulating cellular processes. DKK-1 N terminal Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived DKK-1 N terminal protein, expressed by HEK293, with C-Avi, C-hFc labeled tag. The total length of DKK-1 N terminal Protein, Human (Biotinylated, HEK293, Fc-Avi) is 111 a.a., with molecular weight of 50-60 kDa.
DKK-1 Protein, with co-receptor and lipoprotein receptor binding activities, crucially regulates ossification and neuron death positively. Primarily located in the extracellular space, DKK-1 is implicated in anodontia, showing biased expression in kidney (RPKM 4.7), brain (RPKM 0.6), and two other tissues. Its role in the WNT signaling pathway and impact on visual epilepsy highlight its significance in developmental and neurological contexts. DKK-1 Protein, Rat (HEK293, C-His) is the recombinant rat-derived DKK-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of DKK-1 Protein, Rat (HEK293, C-His) is 239 a.a., with molecular weight of ~38.58 kDa.
DKK-1 Proteinas are potent antagonists of canonical Wnt signaling, inhibiting LRP5/6-Wnt interactions and forming a ternary complex with KREMEN to promote LRP5/6 internalization. In addition to its proapoptotic function by antagonizing KREMEN1 independently of Wnt, DKK-1 also exhibits antiapoptotic activity. DKK-1 Protein, Human (HEK293, C-His) is the recombinant human-derived DKK-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of DKK-1 Protein, Human (HEK293, C-His) is 235 a.a., with molecular weight of 35-50 kDa.
DKK-1 Proteinas, a potent antagonist of canonical Wnt signaling, inhibits LRP5/6-Wnt interaction and forms a ternary complex with KREMEN, facilitating LRP5/6 internalization. Beyond antagonizing KREMEN1's pro-apoptotic function independently of Wnt, DKK-1 exhibits anti-apoptotic activity. Implicated in limb development, it modulates Wnt signaling for normal limb patterning. Interacting with LRP5/6 through its C-terminal Cys-rich domain, DKK-1 attenuates Wnt-mediated signaling influenced by MESD and/or KREMEN, emphasizing its multifaceted role in regulating cellular processes. DKK-1 Protein, Human (235a.a, HEK293, Tag free) is the recombinant human-derived DKK-1 protein, expressed by HEK293, with tag free. The total length of DKK-1 Protein, Human (235a.a, HEK293, Tag free) is 235 a.a., with molecular weight of ~38.31 kDa.
