1. Stem Cell/Wnt
  2. β-catenin
  3. WAY-262611

WAY-262611 

Cat. No.: HY-11035 Purity: 99.24%
Handling Instructions

WAY-262611 is a wingless β-Catenin agonist that increases bone formation rate with an EC50 of 0.63 μM in TCF-Luciferase assay. WAY-262611 is also a Dkk1 inhibitor.

For research use only. We do not sell to patients.

WAY-262611 Chemical Structure

WAY-262611 Chemical Structure

CAS No. : 1123231-07-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 161 In-stock
Estimated Time of Arrival: December 31
10 mg USD 146 In-stock
Estimated Time of Arrival: December 31
50 mg USD 498 In-stock
Estimated Time of Arrival: December 31
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200 mg   Get quote  

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Customer Review

Based on 4 publication(s) in Google Scholar

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Description

WAY-262611 is a wingless β-Catenin agonist that increases bone formation rate with an EC50 of 0.63 μM in TCF-Luciferase assay. WAY-262611 is also a Dkk1 inhibitor.

IC50 & Target

EC50: 0.63 μM (β-Catenin)[1]

In Vitro

WAY-262611 has the most potent activity in the primary assay, low kinase inhibition potential, and high solubility[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

WAY-262611 has excellent pharmacokinetic properties and shows a dose dependent increase in the trabecular bone formation rate in ovariectomized rats following oral administration. Calvariae from wt mice treated with WAY-262611 shows statistically increased BFR, while similarly treated KO animals are no different from control. This indicates that WAY-262611 is acting via the Wnt β-catenin pathway and most likely through inhibition of Dkk-1[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

318.42

Formula

C₂₀H₂₂N₄

CAS No.

1123231-07-1

SMILES

NCC1CCN(C2=NC=CC(C3=CC=C4C=CC=CC4=C3)=N2)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 42 mg/mL (131.90 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1405 mL 15.7025 mL 31.4051 mL
5 mM 0.6281 mL 3.1405 mL 6.2810 mL
10 mM 0.3141 mL 1.5703 mL 3.1405 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.67 mg/mL (5.24 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.67 mg/mL (5.24 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.67 mg/mL (5.24 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[1]

Rats: WAY-262611 is dissolved in DMSO and diluted with saline for iv (Rats). WAY-262611 is prepared in 0.5% methylcellulose/2% Tween-80 for po OVX rats14 are treated orally with 5 (po, vehicle=0.5% methylcellulose/2% Tween-80, qd, 28 days) at four doses. Trabecular bone formation rate (BFR) in the tibia is established in all dose groups at the end of the in-life portion of the study. A clear dose response and activity as low as 0.3 mg/kg/day are observed[1].

Mice: To confirm activity via the Wnt pathway, the calvariae of wild type (wt) and Dkk-1 knockout (KO) mice are treated with 5 once a day for 7 days (DMSO solution, sc injection). The KO animals are not expected to respond because of the inherent inability to inhibit a missing target protein, while wild type animals with fully expressed Dkk-1 are expected to show a pharmacological response [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

WAY-262611WAY262611WAY 262611β-cateninBeta cateninInhibitorinhibitorinhibit

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Product Name:
WAY-262611
Cat. No.:
HY-11035
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