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EWS

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) DNA/RNA Synthesis (5) Isotope-Labeled Compounds (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (5)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Inhibitors & Agonists

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-122903

TK216 5+ Cited Publications	DNA/RNA Synthesis	Cancer
TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor . TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity .

HY-14507

YK-4-279 5+ Cited Publications	DNA/RNA Synthesis Apoptosis	Cancer
YK-4-279 blocks RNA Helicase A (RHA) binding with EWS-FLI1 (oncogenic protein). YK-4-279 induces apoptosis and shows anti-proliferation activities towards various cancer cells. YK-4-279 has a chiral center and it can be separated into two enantiomers. YK-4-279 can be used for the research of cancer .

HY-122903S

TK216-d4	Isotope-Labeled Compounds DNA/RNA Synthesis	Cancer
TK216-d₄ is the deuterium labeled TK216 (HY-122903). TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor . TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity .

HY-163325A

Fli-1-IN-1	DNA/RNA Synthesis	Cancer
Fli-1-IN-1 (compound 21) is a FLI1 targeting agent that directly binds to and inhibits the *EWS-FLI1* protein interaction. EWS-FLI1 can bind to RNA helicase A, and Fli-1-IN-1 inhibits EWS-FLI1 and has potential anticancer activity .

HY-163325

Fli-1-IN-1 fumarate	DNA/RNA Synthesis	Cancer
Fli-1-IN-1 (compound 21) fumarate is a FLI1 targeting agent that directly binds to and inhibits the *EWS-FLI1* protein interaction. EWS-FLI1 can bind to RNA helicase A, and Fli-1-IN-1 fumarate inhibits EWS-FLI1 and has potential anticancer activity .

HY-RS04581

EWSR1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
EWSR1 Human Pre-designed siRNA Set A contains three designed siRNAs for EWSR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

EWSR1 Human Pre-designed siRNA Set A EWSR1 Human Pre-designed siRNA Set A

HY-RS19681

Ewsr1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ewsr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ewsr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ewsr1 Mouse Pre-designed siRNA Set A Ewsr1 Mouse Pre-designed siRNA Set A

Cat. No.	Product Name	Chemical Structure

HY-122903S

TK216-d4
TK216-d₄ is the deuterium labeled TK216 (HY-122903). TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor . TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity .

Host:	Rabbit (4)
Reactivity:	Human (4) Rat (1) Mouse (3)
Application:	IHC-P (4) ICC/IF (4) IF-Tissue (1) WB (4) FC (3)
Isotype:	IgG (4)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (3) Recombinant (3)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82525

	EWSR1 Antibody (YA2270) EWSR1; EWS; RNA-binding protein EWS; EWS oncogene; Ewing sarcoma breakpoint region 1 protein	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	EWSR1 Antibody (YA2270) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to EWSR1.

HY-P810358

	ATF1 Antibody (YA9680) Activating transcription factor 1, ATF 1, atf1, ATF1 EWS fusion gene, ATF1 FUS fusion gene, ATF1_HUMAN, cAMP dependent transcription factor 1, cAMP-dependent transcription factor ATF-1, Cyclic AMP dependent transcription factor ATF 1, Cyclic AMP dependent transcription factor ATF1	WB, ICC/IF, IF-Tissue, IHC-P, FC	Human
	ATF1 Antibody (YA9680) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to ATF1.

HY-P82532

	Wilms Tumor Protein Antibody (YA2277) GUD; AWT1; WAGR; WT33; NPHS4; WIT-2; EWS-WT1; WIT 2 antibody; WT 1 antibody; FWT1 antibody; GUD antibody; NPHS4 antibody; WAGR antibody; Wilms tumor 1 antibody; Wilms Tumor antibody; Wilms tumor protein antibody; Wilms' tumor gene antibody; WIT2 antibody; WT antibody; WT1 antibody; WT1_HUMAN antibody; WT33 antibody	WB, IHC-P, ICC/IF, FC	Human, Mouse
	Wilms Tumor Protein Antibody (YA2277) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Wilms Tumor Protein.

HY-P82532A

	Wilms Tumor Protein Antibody (YA2277)(PBS only) GUD; AWT1; WAGR; WT33; NPHS4; WIT-2; EWS-WT1; WIT 2 antibody; WT 1 antibody; FWT1 antibody; GUD antibody; NPHS4 antibody; WAGR antibody; Wilms tumor 1 antibody; Wilms Tumor antibody; Wilms tumor protein antibody; Wilms' tumor gene antibody; WIT2 antibody; WT antibody; WT1 antibody; WT1_HUMAN antibody; WT33 antibody	WB, IHC-P, ICC/IF, FC	Human, Mouse
	Wilms Tumor Protein Antibody (YA2277) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Wilms Tumor Protein.

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EWSR1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
EWSR1 Human Pre-designed siRNA Set A contains three designed siRNAs for EWSR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ewsr1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ewsr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ewsr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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