ATF1 Antibody (YA9680)
(Synonyms: Activating transcription factor 1, ATF 1, atf1, ATF1 EWS fusion gene, ATF1 FUS fusion gene, ATF1_HUMAN, cAMP dependent transcription factor 1, cAMP-dependent transcription factor ATF-1, Cyclic AMP dependent transcription factor ATF 1, Cyclic AMP dependent transcription factor ATF1)ATF1 Antibody (YA9680) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to ATF1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF, IF-Tissue, IHC-P, FC
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Reactivity :
Human
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Formulation:
Supplied in TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
1
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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|---|---|---|---|---|---|
| Dilution Ratio | 1:50-200 | 1:50-200 | 1:50-200 | 1:50-100 |
Product Details
ATF1 Antibody (YA9680) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to ATF1.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 29 kDa;
Synthetic peptide of Human ATF1 (aa 222-271).
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ATF1 is a This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation
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Subcellular Localization
Nucleus
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Isoforms & Post-Translational Modification
ATF1 has 2 isoforms, P18846-1: amino acid length is 271, molecular weight is 29233 Da (predicted); P18846-2: amino acid length is 136, molecular weight is 15295 Da (predicted).
Phosphorylated at Ser-198 by HIPK2 in response to genotoxic stress. This phosphorylation promotes transcription repression of FTH1 and other antioxidant detoxification genes. The CDK3-mediated phosphorylation at Ser-63 promotes its transactivation and transcriptional activities. Phosphorylated at Ser-63 by RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli -
Subunit
Binds DNA as a dimer.
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SwissProt ID
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Synonyms
Activating transcription factor 1, ATF 1, atf1, ATF1 EWS fusion gene, ATF1 FUS fusion gene, ATF1_HUMAN, cAMP dependent transcription factor 1, cAMP-dependent transcription factor ATF-1, Cyclic AMP dependent transcription factor ATF 1, Cyclic AMP dependent transcription factor ATF1
Documentation
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