2. Others Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis Isotope-Labeled Compounds
  4. TK216-d4

TK216-d4 is the deuterium labeled TK216 (HY-122903). TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor. TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity.

For research use only. We do not sell to patients.

TK216-d<sub>4</sub>

TK216-d4 Chemical Structure

CAS No. : 3034816-36-6

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Other Forms of TK216-d4:

TK216-d4 Related Antibodies

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Description

TK216-d4 is the deuterium labeled TK216 (HY-122903). TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor[1]. TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity[2].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

IC50 & Target

Helicase

 

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TK216-d4 Related Antibodies
Molecular Weight

380.26

Formula

C19H11D4Cl2NO3
CAS No.
Unlabeled CAS
Appearance

Solid

Color

White to off-white

SMILES

O=C1NC2=C(C1(O)CC(C3=C([2H])C([2H])=C(C([2H])=C3[2H])C4CC4)=O)C(Cl)=CC=C2Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
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TK216-d4 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TK216-d43034816-36-6DNA/RNA SynthesisIsotope-Labeled CompoundsInhibitorinhibitorinhibit

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TK216-d4
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HY-122903S
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