1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis

YK-4-279 

Cat. No.: HY-14507 Purity: 99.61%
Handling Instructions

YK 4-279 is an inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1. YK-4-279 inhibits Ewing's sarcoma family tumor (ESFT) cell growth; YK-4-279 induces apoptosis.

For research use only. We do not sell to patients.

YK-4-279 Chemical Structure

YK-4-279 Chemical Structure

CAS No. : 1037184-44-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 106 In-stock
Estimated Time of Arrival: December 31
10 mg USD 96 In-stock
Estimated Time of Arrival: December 31
50 mg USD 370 In-stock
Estimated Time of Arrival: December 31
100 mg USD 678 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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    YK-4-279 purchased from MCE. Usage Cited in: Int J Med Sci. 2017 Apr 7;14(4):356-366.

    Effects of Docetaxel and YK-4-279 alone or in combination on the levels of ETV1, AR, PSA, p-STAT3, survivin, Bcl-2 and p-Akt in LNCaP and PC-3 cells. LNCaP and PC-3 cells are cultured at a density of 1 × 105 cells/mL in 100 mm tissue culture dishes (10 mL/dish) for 24 h. The cells are then treated with Docetaxel (0.5 nM) and YK-4-279(0.5 µM) alone or in combination for 24 h (for analysis of p-Akt, survivin, PSA, p-STAT3 and AR) and 48 h (for analysis of Bcl-2). The levels of AR,Bcl-2,
    • Biological Activity

    • Technical Information

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    • References

    Description

    YK 4-279 is an inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1. YK-4-279 inhibits Ewing's sarcoma family tumor (ESFT) cell growth; YK-4-279 induces apoptosis. IC50 value: Target: RNA Helicase A ES-FLI1 is an oncogenic fusion protein found in Ewing’s sarcoma, a family of undifferentiated tumors that occur throughout the body. The binding of RNA helicase A (RHA) to ES-FLI1 promotes its oncogenic function. YK-4-279 is an inhibitor of protein-protein interactions between ES-FLI1 and RHA. At 10 μM, YK-4-279 blocks RHA binding to ES-FLI1 and induces apoptosis of a panel of Ewing’s sarcoma tumor cell lines with IC50 values ranging from 0.5-2 μM. At 1.5 mg per dose, YK-4-279 reduces the growth of Ewing’s sarcoma orthotopic xenografts in mice after treatment with the inhibitor for two weeks.

    Solvent & Solubility
    In Vitro: 

    10 mM in DMSO

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.7307 mL 13.6537 mL 27.3075 mL
    5 mM 0.5461 mL 2.7307 mL 5.4615 mL
    10 mM 0.2731 mL 1.3654 mL 2.7307 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    366.20

    Formula

    C₁₇H₁₃Cl₂NO₄

    CAS No.

    1037184-44-3

    SMILES

    ClC1=C2C(C(O)(CC(C3=CC=C(OC)C=C3)=O)C(N2)=O)=C(Cl)C=C1

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

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    Product Name:
    YK-4-279
    Cat. No.:
    HY-14507
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    YK-4-279

    Cat. No.: HY-14507