VPC-18005
Based on 1 Customer Validation
VPC-18005 inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain, and disrupts the ERG binding to DNA. VPC-18005 is a potent inhibitor of luciferase activity.
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- Reinheit: 99.80%
- CAS. Nr.: 2242480-48-2
- Formel: C15H17N3O3S
- Molecular Weight:319.38
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Speicherung:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
VPC-18005 is found to inhibit pETS-luc reporter activity in PNT1B-ERG and VCaP cells with IC50 values of 3 and 6 μM, respectively[1].
VPC-18005 could suppress ERG reporter activity without exhibiting overt cytotoxicity[1].
VPC-18005 inhibits migration and invasion of ERG-overexpressing cells in vitro[1].
VPC-18005 can antagonize the metastatic potential of ERG-expressing prostate cells[1].
The exposure of larvae to 1 or 10 μM of VPC-18005 produced a 20–30% decrease in the dissemination of cancer cells in zebrafsh[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PNT1B-Mock cells and PNT1B-ERG cells.
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Concentration:5 µM.
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Incubation Time:24 h.
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Result:Inhibited migration and invasion of prostate cell lines in vitro.
Chemical Information
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CAS. Nr. 2242480-48-2
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Appearance Solid
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Molecular Weight 319.38
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Formel C15H17N3O3S
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Color White to off-white
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SMILES
O=C(O)CC(S/C(N1)=N\N=C/C2=CC=C(C(C)C)C=C2)C1=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Lösungsmittel & Löslichkeit
DMSO : 62.5 mg/mL (195.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Miriam S Butler, et al. Discovery and characterization of small molecules targeting the DNA-binding ETS domain of ERG in prostate cancer. Oncotarget. 2017 Jun 27;8(26):42438-42454. [Content Brief]
[2]. Haneen Amawi, et al. The use of zebrafish model in prostate cancer therapeutic development and discovery. Cancer Chemother Pharmacol. 2021 Mar;87(3):311-325. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1311 mL | 15.6553 mL | 31.3107 mL | 78.2767 mL |
| 5 mM | 0.6262 mL | 3.1311 mL | 6.2621 mL | 15.6553 mL | |
| 10 mM | 0.3131 mL | 1.5655 mL | 3.1311 mL | 7.8277 mL | |
| 15 mM | 0.2087 mL | 1.0437 mL | 2.0874 mL | 5.2184 mL | |
| 20 mM | 0.1566 mL | 0.7828 mL | 1.5655 mL | 3.9138 mL | |
| 25 mM | 0.1252 mL | 0.6262 mL | 1.2524 mL | 3.1311 mL | |
| 30 mM | 0.1044 mL | 0.5218 mL | 1.0437 mL | 2.6092 mL | |
| 40 mM | 0.0783 mL | 0.3914 mL | 0.7828 mL | 1.9569 mL | |
| 50 mM | 0.0626 mL | 0.3131 mL | 0.6262 mL | 1.5655 mL | |
| 60 mM | 0.0522 mL | 0.2609 mL | 0.5218 mL | 1.3046 mL | |
| 80 mM | 0.0391 mL | 0.1957 mL | 0.3914 mL | 0.9785 mL | |
| 100 mM | 0.0313 mL | 0.1566 mL | 0.3131 mL | 0.7828 mL |
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