2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. Fli-1-IN-1 fumarate

Fli-1-IN-1 (compound 21) fumarate is a FLI1 targeting agent that directly binds to and inhibits the EWS-FLI1 protein interaction. EWS-FLI1 can bind to RNA helicase A, and Fli-1-IN-1 fumarate inhibits EWS-FLI1 and has potential anticancer activity.

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Fli-1-IN-1 fumarate

Fli-1-IN-1 fumarate Chemical Structure

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Other Forms of Fli-1-IN-1 fumarate:

Fli-1-IN-1 fumarate Related Antibodies

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Description

Fli-1-IN-1 (compound 21) fumarate is a FLI1 targeting agent that directly binds to and inhibits the EWS-FLI1 protein interaction. EWS-FLI1 can bind to RNA helicase A, and Fli-1-IN-1 fumarate inhibits EWS-FLI1 and has potential anticancer activity[1].

IC50 & Target

Helicase

 

Cellular Effect
Cell Line Type Value Description References
HEL IC50
0.19 μM
Compound: (+/-)-21
Cytotoxicity against HEL cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Cytotoxicity against HEL cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 38253024]
MDA-MB-231 IC50
> 1 μM
Compound: (+/-)-21
Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 38253024]
SW480 IC50
> 1 μM
Compound: (+/-)-21
Cytotoxicity against human SW480 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Cytotoxicity against human SW480 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 38253024]
Molecular Weight

704.81

Formula

C39H48N2O10
SMILES

COC1=CC(OC)=C([C@@]2([C@@H](C[C@H]3C4=CC=CC=C4)O)O)C(O[C@]23C(C=C5)=CC=C5OCCCCCN6CCN(C)CC6)=C1.O=C(O)/C=C/C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Fli-1-IN-1 fumarate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fli-1-IN-1DNA/RNA SynthesisEWS-FLI1 protein interactionInhibitorinhibitorinhibit

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Fli-1-IN-1 fumarate
Cat. No.:
HY-163325
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