Fli-1-IN-1 fumarate
Fli-1-IN-1 (compound 21) fumarate is a FLI1 targeting agent that directly binds to and inhibits the EWS-FLI1 protein interaction. EWS-FLI1 can bind to RNA helicase A, and Fli-1-IN-1 fumarate inhibits EWS-FLI1 and has potential anticancer activity.
For research use only. We do not sell to patients.
- Formula: C39H48N2O10
- Molecular Weight:704.81
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All DNA/RNA Synthesis Isoforms
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Biological Activity
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Helicase |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEL | IC50 |
0.19 μM
Compound: (+/-)-21
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Cytotoxicity against HEL cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Cytotoxicity against HEL cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
|
[PMID: 38253024] |
| MDA-MB-231 | IC50 |
>1 μM
Compound: (+/-)-21
|
Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
|
[PMID: 38253024] |
| SW480 | IC50 |
>1 μM
Compound: (+/-)-21
|
Cytotoxicity against human SW480 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Cytotoxicity against human SW480 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
|
[PMID: 38253024] |
Chemical Information
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Molecular Weight 704.81
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Formula C39H48N2O10
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SMILES
COC1=CC(OC)=C([C@@]2([C@@H](C[C@H]3C4=CC=CC=C4)O)O)C(O[C@]23C(C=C5)=CC=C5OCCCCCN6CCN(C)CC6)=C1.O=C(O)/C=C/C(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)