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Results for "

IL-6+inhibitor

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

1

Inhibitory Antibodies

3

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-102084
    LMT-28
    10+ Cited Publications

    		 Interleukin Related Inflammation/Immunology
    LMT-28 is an orally active and the first synthetic IL-6 inhibitor that functions through direct binding to gp130. LMT-28 shows low toxicity and selectively inhibits IL-6-induced phosphorylation of STAT3, JAK2, and gp130 .
    LMT-28
  • HY-P99505
    Ziltivekimab

    COR-001; MEDI-5117; MEDI-5117; NN-6018; WBP-216

    		 Interleukin Related LDLR Inflammation/Immunology Endocrinology
    Ziltivekimab (COR-001) is a fully human monoclonal antibody and also an IL-6 inhibitor. Ziltivekimab significantly reduces inflammatory biomarkers and Lipoprotein (a) in chronic kidney disease patients with systemic inflammation. Ziltivekimab does not increase pro-atherosclerotic lipid levels. Ziltivekimab is used in studies related to atherosclerotic thrombotic diseases and chronic kidney disease .
    Ziltivekimab
  • HY-177063
    IL-6-IN-2

    		Interleukin Related Infection Inflammation/Immunology
    IL-6-IN-2 is an interleukin-6 (IL-6) inhibitor. IL-6-IN-2 binds to IL-6 at Lys66, Phe74, Gln175, Ser176, and Arg179 via π-π, π-alkyl, hydrogen bond, and hydrophobic interactions to block IL-6/IL-6R heterocomplex formation. IL-6-IN-2 exhibits low gastrointestinal absorption rate. IL-6-IN-2 can be used for the research of cytokine release syndrome, covid-19 .
    IL-6-IN-2
  • HY-177281
    IL-6-IN-3

    		Interleukin Related Inflammation/Immunology Cancer
    IL-6-IN-3 (Example 4) is an IL-6 inhibitor with an IC50 of 0.4 nM. IL-6-IN-3 can be used for cancers like prostate cancer and arthritis like rheumatoid arthritis research .
    IL-6-IN-3
  • HY-117511
    HJC0123

    		STAT Apoptosis Interleukin Related TGF-beta/Smad Others
    HJC0123 is a STAT3 inhibitor. HJC0123 inhibits the proliferation of hepatic stellate cells and induces cell cycle arrest and apoptosis. HJC0123 reduces the phosphorylation, nuclear translocation and transcriptional activities of STAT3, increases the production of IL-6, inhibits the phosphorylation of Smad2/3 and down-regulates SOCS3. HJC0123 can be used in the study of liver fibrosis .
    HJC0123
  • HY-N14325
    Madindoline B

    		Interleukin Related Infection
    Madindoline B is an IL-6 inhibitor. Madindoline B inhibits IL-6-dependent MH-60 cells and has no inhibitory effect on IL-6-independent MH-60 cells. In the presence of 0.1 U/mL IL-6, it inhibits IL-6-dependent MH-60 cells with an IC50 of 30 μM. Madindoline B has no antimicrobial effect .
    Madindoline B
  • HY-162681
    eeAChE-IN-3

    		Cholinesterase (ChE) Interleukin Related Neurological Disease
    eeAChE-IN-3 (compound YS3g) is an orally active, potent EeAChE and IL-6 inhibitor with IC50s of 0.54 μM, 0.49 μM, 8.54 μM and 0.57 μM for EeAChE, RatAChE, RatBuChE and IL-6, respectively. eeAChE-IN-3 improves STZ (HY-13753) (Streptozotocin; HY-13753)-induced learning and memory impairment in mice. eeAChE-IN-3 has the potential for Alzheimer's disease (AD) research .
    eeAChE-IN-3
  • HY-N19725
    Calonysterone

    		Interleukin Related Metabolic Disease
    Calonysterone is an orally effective IL-6 inhibitor. Calonysterone reduces the level of the proinflammatory cytokine IL-6. Calonysterone prevents diet-induced obesity. Calonysterone normalizes abnormal plasma adiponectin and leptin concentrations. Calonysterone increases the percentage of total DNA methylation. Calonysterone enhances antioxidant activity. Calonysterone is applicable to obesity-related research .
    Calonysterone
  • HY-102084R
    LMT-28 (Standard)

    		Reference Standards Interleukin Related Inflammation/Immunology
    LMT-28 (Standard) is the analytical standard of LMT-28 (HY-102084). This product is intended for research and analytical applications. LMT-28 is an orally active and the first synthetic IL-6 inhibitor that functions through direct binding to gp130. LMT-28 shows low toxicity and selectively inhibits IL-6-induced phosphorylation of STAT3, JAK2, and gp130 .
    LMT-28 (Standard)
  • HY-N17562
    Acutissimalignan B

    		NO Synthase Interleukin Related IKK NF-κB Inflammation/Immunology
    Acutissimalignan B is a natural product. Acutissimalignan B can be isolated from Daphne kiusiana var. atrocaulis (Rehd.) F. Maekawa. Acutissimalignan B can reduce the mRNA expression of inflammatory cytokines (iNOS, TNF-α, IL-1β, and IL-6), inhibit the phosphorylation of IκBα, and inhibit the nuclear translocation of NK-κB p65. Acutissimalignan B shows anti-neuroinflammatory effects .
    Acutissimalignan B

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