Calonysterone
Calonysterone is an orally effective IL-6 inhibitor. Calonysterone reduces the level of the proinflammatory cytokine IL-6. Calonysterone prevents diet-induced obesity. Calonysterone normalizes abnormal plasma adiponectin and leptin concentrations. Calonysterone increases the percentage of total DNA methylation. Calonysterone enhances antioxidant activity. Calonysterone is applicable to obesity-related research.
For research use only. We do not sell to patients.
- CAS No.: 51787-31-6
- Formula: C27H40O7
- Molecular Weight:476.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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IL-6 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male, 6 weeks old, obesity induced by 12-week high-fat, high-sugar diet)[1]
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Dosage:10 mg/kg
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Administration:p.o.; daily; 12 weeks
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Result:Fully prevented HFHSD-induced body weight gain.
Normalized plasma leptin and adiponectin levels altered by HFHSD.
Significantly increased liver total antioxidant capacity and catalase levels compared to the HFHSD group.
Did not change liver superoxide dismutase levels relative to the standard diet control.
Counteracted HFHSD-induced increases in liver IL-6 mRNA and protein expression, and decreased plasma IL-6 levels.
Significantly increased global DNA methylation in the liver compared to the standard diet control group.
Chemical Information
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CAS No. 51787-31-6
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Molecular Weight 476.60
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Formula C27H40O7
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SMILES
C[C@@]12C3=C(C(C(O)=C1C[C@H]([C@H](C2)O)O)=O)C4=CC[C@@]([C@@](C)(O)[C@H](O)CCC(C)(O)C)([H])[C@]4(CC3)C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Osman AA, et al. Investigation of calonysterone and 20-hydroxyecdysone effects in high-fat, high-sugar diet-induced obesity rat model. Heliyon. 2025;11(3):e42435. Published 2025 Feb 4. [Content Brief]
[2]. Khaliq-uz-Zaman SM, et al. Chemical constituents from Asparagus dumosus. Fitoterapia. 2000;71(3):331-333. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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