Calonysterone
Calonysterone is an orally effective IL-6 inhibitor. Calonysterone reduces the level of the proinflammatory cytokine IL-6. Calonysterone prevents diet-induced obesity. Calonysterone normalizes abnormal plasma adiponectin and leptin concentrations. Calonysterone increases the percentage of total DNA methylation. Calonysterone enhances antioxidant activity. Calonysterone is applicable to obesity-related research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 51787-31-6
- 分子式: C27H40O7
- 分子量:476.60
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
|
IL-6 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Sprague-Dawley (male, 6 weeks old, obesity induced by 12-week high-fat, high-sugar diet)[1]
-
Dosage:10 mg/kg
-
Administration:p.o.; daily; 12 weeks
-
Result:Fully prevented HFHSD-induced body weight gain.
Normalized plasma leptin and adiponectin levels altered by HFHSD.
Significantly increased liver total antioxidant capacity and catalase levels compared to the HFHSD group.
Did not change liver superoxide dismutase levels relative to the standard diet control.
Counteracted HFHSD-induced increases in liver IL-6 mRNA and protein expression, and decreased plasma IL-6 levels.
Significantly increased global DNA methylation in the liver compared to the standard diet control group.
化学情報
-
CAS 番号 51787-31-6
-
分子量 476.60
-
分子式 C27H40O7
-
SMILES
C[C@@]12C3=C(C(C(O)=C1C[C@H]([C@H](C2)O)O)=O)C4=CC[C@@]([C@@](C)(O)[C@H](O)CCC(C)(O)C)([H])[C@]4(CC3)C
-
Structure Classification
-
Initial Source
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Osman AA, et al. Investigation of calonysterone and 20-hydroxyecdysone effects in high-fat, high-sugar diet-induced obesity rat model. Heliyon. 2025;11(3):e42435. Published 2025 Feb 4. [Content Brief]
[2]. Khaliq-uz-Zaman SM, et al. Chemical constituents from Asparagus dumosus. Fitoterapia. 2000;71(3):331-333. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Powered by Bioz