2. Immunology/Inflammation
  3. Interleukin Related
  4. Calonysterone

Calonysterone is an orally effective IL-6 inhibitor. Calonysterone reduces the level of the proinflammatory cytokine IL-6. Calonysterone prevents diet-induced obesity. Calonysterone normalizes abnormal plasma adiponectin and leptin concentrations. Calonysterone increases the percentage of total DNA methylation. Calonysterone enhances antioxidant activity. Calonysterone is applicable to obesity-related research.

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Calonysterone

Calonysterone Chemical Structure

CAS No. : 51787-31-6

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Calonysterone Related Antibodies

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Description

Calonysterone is an orally effective IL-6 inhibitor. Calonysterone reduces the level of the proinflammatory cytokine IL-6. Calonysterone prevents diet-induced obesity. Calonysterone normalizes abnormal plasma adiponectin and leptin concentrations. Calonysterone increases the percentage of total DNA methylation. Calonysterone enhances antioxidant activity. Calonysterone is applicable to obesity-related research[1].

IC50 & Target[1]

IL-6

 

In Vivo

Calonysterone (10 mg/kg; p.o.; daily; 12 weeks) fully prevents high-fat, high-sugar diet-induced obesity in male Sprague-Dawley rats, normalizes adipokine levels, enhances liver antioxidant capacity, reduces inflammatory IL-6 levels, and increases hepatic global DNA methylation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley (male, 6 weeks old, obesity induced by 12-week high-fat, high-sugar diet)[1]
Dosage: 10 mg/kg
Administration: p.o.; daily; 12 weeks
Result: Fully prevented HFHSD-induced body weight gain.
Normalized plasma leptin and adiponectin levels altered by HFHSD.
Significantly increased liver total antioxidant capacity and catalase levels compared to the HFHSD group.
Did not change liver superoxide dismutase levels relative to the standard diet control.
Counteracted HFHSD-induced increases in liver IL-6 mRNA and protein expression, and decreased plasma IL-6 levels.
Significantly increased global DNA methylation in the liver compared to the standard diet control group.
Molecular Weight

476.60

Formula

C27H40O7
CAS No.
SMILES

C[C@@]12C3=C(C(C(O)=C1C[C@H]([C@H](C2)O)O)=O)C4=CC[C@@]([C@@](C)(O)[C@H](O)CCC(C)(O)C)([H])[C@]4(CC3)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Calonysterone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Calonysterone51787-31-6Interleukin RelatedILadiponectinantioxidant activityinflammatory cytokineSprague-Dawley ratsinterleukin-6Asparagus dumosusobesityDNA methylationleptindiet-induced obese rodent modelsInhibitorinhibitorinhibit

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