2. JAK/STAT Signaling Stem Cell/Wnt Apoptosis Immunology/Inflammation TGF-beta/Smad
  3. STAT Apoptosis Interleukin Related TGF-beta/Smad
  4. HJC0123

HJC0123 is a STAT3 inhibitor. HJC0123 inhibits the proliferation of hepatic stellate cells and induces cell cycle arrest and apoptosis. HJC0123 reduces the phosphorylation, nuclear translocation and transcriptional activities of STAT3, increases the production of IL-6, inhibits the phosphorylation of Smad2/3 and down-regulates SOCS3. HJC0123 can be used in the study of liver fibrosis.

For research use only. We do not sell to patients.

HJC0123

HJC0123 Chemical Structure

CAS No. : 1430420-02-2

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
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HJC0123 Related Antibodies

Top Publications Citing Use of Products

View All STAT Isoform Specific Products:

View All Isoforms
STAT3 STAT5 STAT6 STAT1

View All Interleukin Related Isoform Specific Products:

View All Isoforms
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

HJC0123 is a STAT3 inhibitor. HJC0123 inhibits the proliferation of hepatic stellate cells and induces cell cycle arrest and apoptosis. HJC0123 reduces the phosphorylation, nuclear translocation and transcriptional activities of STAT3, increases the production of IL-6, inhibits the phosphorylation of Smad2/3 and down-regulates SOCS3. HJC0123 can be used in the study of liver fibrosis[1].

IC50 & Target[1]

STAT3

 

IL-6

 

Cellular Effect
Cell Line Type Value Description References
ASPC1 IC50
1.25 μM
Compound: 5, HJC0123
CYtotoxicity against human AsPC1 cells by MTS assay
CYtotoxicity against human AsPC1 cells by MTS assay
[PMID: 23416191]
MCF7 IC50
0.1 μM
Compound: 5, HJC0123
CYtotoxicity against ER-positive human MCF7 cells by MTS assay
CYtotoxicity against ER-positive human MCF7 cells by MTS assay
[PMID: 23416191]
MDA-MB-231 IC50
0.29 μM
Compound: 5, HJC0123
CYtotoxicity against ER-negative human MDA-MB-231 cells by MTS assay
CYtotoxicity against ER-negative human MDA-MB-231 cells by MTS assay
[PMID: 23416191]
PANC-1 IC50
0.26 μM
Compound: 5, HJC0123
CYtotoxicity against human PANC1 cells by MTS assay
CYtotoxicity against human PANC1 cells by MTS assay
[PMID: 23416191]
Molecular Weight

412.46

Formula

C24H16N2O3S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NC1=CC=C(C2=C1)C=CS2(=O)=O)C3=CC(C4=CC=CC=C4)=NC5=CC=CC=C35
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (121.22 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4245 mL 12.1224 mL 24.2448 mL
5 mM 0.4849 mL 2.4245 mL 4.8490 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4245 mL 12.1224 mL 24.2448 mL 60.6119 mL
5 mM 0.4849 mL 2.4245 mL 4.8490 mL 12.1224 mL
10 mM 0.2424 mL 1.2122 mL 2.4245 mL 6.0612 mL
15 mM 0.1616 mL 0.8082 mL 1.6163 mL 4.0408 mL
20 mM 0.1212 mL 0.6061 mL 1.2122 mL 3.0306 mL
25 mM 0.0970 mL 0.4849 mL 0.9698 mL 2.4245 mL
30 mM 0.0808 mL 0.4041 mL 0.8082 mL 2.0204 mL
40 mM 0.0606 mL 0.3031 mL 0.6061 mL 1.5153 mL
50 mM 0.0485 mL 0.2424 mL 0.4849 mL 1.2122 mL
60 mM 0.0404 mL 0.2020 mL 0.4041 mL 1.0102 mL
80 mM 0.0303 mL 0.1515 mL 0.3031 mL 0.7576 mL
100 mM 0.0242 mL 0.1212 mL 0.2424 mL 0.6061 mL
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HJC0123 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HJC01231430420-02-2HJC 0123HJC-0123STATApoptosisInterleukin RelatedTGF-beta/SmadILTransforming growth factor betaHepatic stellate cellsInhibitorinhibitorinhibit

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