Acutissimalignan B 

Acutissimalignan B is a natural product. Acutissimalignan B can be isolated from Daphne kiusiana var. atrocaulis (Rehd.) F. Maekawa. Acutissimalignan B can reduce the mRNA expression of inflammatory cytokines (iNOS, TNF-α, IL-1β, and IL-6), inhibit the phosphorylation of IκBα, and inhibit the nuclear translocation of NK-κB p65. Acutissimalignan B shows anti-neuroinflammatory effects^[1].

Acutissimalignan B inhibits LPS-induced NO production in LPS-induced BV-2 microglial cells with an IC₅₀ of 5.41 μM^[1].
Acutissimalignan B (1-10 μM; 2 h pretreatment) reduces mRNA expression of NOS, TNF-α, IL-1β, and IL-6 in LPS-induced BV-2 microglial cells^[1].
Acutissimalignan B (1-10 μM; 2 h pretreatment) inhibits the NF-κB signaling pathway in LPS-induced BV-2 microglial cells by increasing IκBα levels, decreasing IκBα phosphorylation, and blocking NF-κB p65 nuclear translocation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Acutissimalignan B (10 mg/kg; i.g.; 3 days) exerts anti-neuroinflammatory effects in LPS-induced neuroinflammatory mice by inhibiting microglial activation, inflammatory factor expression, and the NF-κB signaling pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

356.37

C₂₀H₂₀O₆

1005390-47-5

COC(C=C1/C=C(C(OC2)=O)\[C@@H]2CC3=CC(OC)=C(C=C3)O)=C(C=C1)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Bai Z, et al. Acutissimalignan B from traditional herbal medicine Daphne kiusiana var. atrocaulis (Rehd.) F. Maekawa inhibits neuroinflammation via NF-κB Signaling pathway. Phytomedicine. 2021;84:153508.  [Content Brief]