Dichapetalin-type triterpenoids and lignans from the aerial parts of Phyllanthus acutissima

  • J Nat Prod. 2008 Apr;71(4):655-63. doi: 10.1021/np7007347.
Patoomratana Tuchinda  1 ,  Jittra Kornsakulkarn ,  Manat Pohmakotr ,  Palangpon Kongsaeree ,  Samran Prabpai ,  Chalobon Yoosook ,  Jitra Kasisit ,  Chanita Napaswad ,  Samaisukh Sophasan ,  Vichai Reutrakul
Affiliations
  • 1. Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand. [email protected]
PMID: 18271551 DOI: 10.1021/np7007347
Abstract

Chemical investigation of the aerial parts of Phyllanthus acutissima resulted in the isolation of five new dichapetalin-type triterpenoids, acutissimatriterpenes A-E ( 1- 5), and two new Lignans, acutissimalignans A ( 6) and B ( 7), along with two known Lignans and three known ellagic acid derivatives. The structures of 1- 7 were determined mainly on the basis of spectroscopic methods. The compounds obtained were evaluated for cytotoxic and anti-HIV-1 activities.