Madindoline B
Madindoline B is an IL-6 inhibitor. Madindoline B inhibits IL-6-dependent MH-60 cells and has no inhibitory effect on IL-6-independent MH-60 cells. In the presence of 0.1 U/mL IL-6, it inhibits IL-6-dependent MH-60 cells with an IC50 of 30 μM. Madindoline B has no antimicrobial effect.
For research use only. We do not sell to patients.
- CAS No.: 184877-65-4
- Formula: C22H27NO4
- Molecular Weight:369.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MH60 | IC50 |
30 μM
Compound: Madindoline B
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Cytotoxicity in mouse MH60 cells assessed as inhibition of recombinant human IL-6-induced growth incubated for 72 hrs by tetrazolium method
Cytotoxicity in mouse MH60 cells assessed as inhibition of recombinant human IL-6-induced growth incubated for 72 hrs by tetrazolium method
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[PMID: 36971365] |
Chemical Information
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CAS No. 184877-65-4
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Molecular Weight 369.45
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Formula C22H27NO4
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SMILES
O[C@@](C1=CC=CC=C12)(CCO3)[C@@]3([H])N2C[C@@]4(C(C(CCCC)=C(C4=O)C)=O)C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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