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Isoforms Recommended: Kinesin-5/Eg5/KSP
Results for "

KSP

" in MedChemExpress (MCE) Product Catalog:

14

Inhibitors & Agonists

2

MCE Kits

2

Recombinant Proteins

1

Isotope-Labeled Compounds

1

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-15187
    Filanesib
    5 Publications Verification

    ARRY-520

    		 Kinesin Apoptosis Cancer
    Filanesib (ARRY-520) is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC50 of 6 nM for human KSP. Filanesib induces cell death by apoptosis in vitro. Filanesib has potent anti-proliferative activity .
    Filanesib
  • HY-124790
    KSP-IA

    		Kinesin Cancer
    KSP-IA (compound 17) is a potent kinesin spindle protein (KSP) inhibitor with an IC50 value of 3.6 nM. KSP-IA inhibits cell mitosis .
    <em>KSP</em>-IA
  • HY-14661
    SB-743921 free base

    		Kinesin Cancer
    SB-743921 free base is a potent selective inhibitor of the mitotic kinesin KSP (Eg5), with a Ki of 0.1 nM. SB-743921 free base can induce mitotic arrest, block cell cycle progression, induce apoptosis, and can be used in the research of myeloma, leukemia and other diseases .
    SB-743921 free base
  • HY-15187C
    Filanesib hydrochloride

    ARRY-520 hydrochloride

    		 Kinesin Apoptosis Neurological Disease
    Filanesib (ARRY-520) hydrochloride is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC50 of 6 nM for human KSP. Filanesib induces cell death by apoptosis in vitro. Filanesib has potent anti-proliferative activity .
    Filanesib hydrochloride
  • HY-15187B
    Filanesib TFA

    ARRY-520 TFA

    		 Kinesin Cancer
    Filanesib TFA (ARRY-520 TFA) is a selective kinesin spindle protein (KSP) inhibitor, with an IC50 of 6 nM for human KSP. Filanesib TFA induces cell death by apoptosis in vitro. Filanesib TFA has potent anti-proliferative activity .
    Filanesib TFA
  • HY-50759
    Ispinesib
    5 Publications Verification

    SB-715992

    		 Kinesin Apoptosis Cancer
    Ispinesib is a specific inhibitor of kinesin spindle protein (KSP), with a Ki app of 1.7 nM.
    Ispinesib
  • HY-12069
    SB-743921 hydrochloride
    3 Publications Verification

    		 Kinesin Cancer
    SB-743921 hydrochloride is a potent inhibitor of the mitotic kinesin KSP (Eg5), with a Ki of 0.1 nM.
    SB-743921 hydrochloride
  • HY-157338
    NHS-Ala-Ala-Asn-active metabolite

    		ADC Linker Kinesin Cancer
    NHS-Ala-Ala-Asn-active metabolite is a cleavable antibody-drug conjugate (ADC) linker for synthesis of kinesin spindle protein (KSP)inhibitor .
    NHS-Ala-Ala-Asn-active metabolite
  • HY-15187A
    (R)-Filanesib

    (R)-ARRY-520

    		 Kinesin Cancer
    (R)-Filanesib ((R)-ARRY-520) is the R-enantiomer of Filanesib (HY-15187). Filanesib is a synthetic kinesin spindle protein (KSP) inhibitor with an IC50 of 6 nM.
    (R)-Filanesib
  • HY-162292
    Anticancer agent 190

    		PI3K Kinesin Cancer
    Anticancer agent 190 (compound 3e) is an inhibitor targeting KSP (Kinesin) and PI3Kδ with activity against breast cancer .
    Anticancer agent 190
  • HY-50759S
    Ispinesib-d5

    SB-715992-d5

    		 Kinesin Apoptosis Cancer
    Ispinesib-d5 (SB-715992-d5) is a deuterium labeled Ispinesib (HY-50759). Ispinesib is a specific inhibitor of kinesin spindle protein (KSP) .
    Ispinesib-d5
  • HY-50672
    MK-0731

    		Kinesin Apoptosis Lipoxygenase Cancer
    MK-0731 is a selective, non-competitive and allosteric kinesin spindle protein (KSP) inhibitor with an IC50 of 2.2 nM and a pKa of 7.6. MK-0731 is >20,000 fold selectivity against other kinesins. MK-0731 induces mitotic arrest and induces apoptosis in tumors. MK-0731 provides significant antitumor efficacy .
    MK-0731
  • HY-13224
    AZD4877

    		Kinesin Apoptosis Cancer
    AZD4877 is another isostere to Ispinesib (HY-50759)and also a kinesin spindle protein (Eg5) inhibitor with IC50 of 2 nM.AZD4877 arrests cell mitosis, leads to the formation of the monopolar spindle phenotype and induces apoptosis. AZD4877 inhibits circulating peripheral blood mononuclear cells (PBMCs) and has anti-cancer activity .
    AZD4877
  • HY-149416
    Mal-PEG8-Val-Ala-PAB-SB-743921

    		Drug-Linker Conjugates for ADC Cancer
    Mal-PEG8-Val-Ala-PAB-SB-743921 (Compound D7) is a Drug-Linker Conjugates for ADC. Mal-PEG8-Val-Ala-PAB-SB-743921 consists of KSP inhibitor SB-743921 (HY-14661) and a linker. Mal-PEG8-Val-Ala-PAB-SB-743921 can be used for synthesis of ADCs .
    Mal-PEG8-Val-Ala-PAB-SB-743921

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