Ispinesib-d5
Based on 1 Customer Validation
Ispinesib-d5 (SB-715992-d5) is a deuterium labeled Ispinesib (HY-50759). Ispinesib is a specific inhibitor of kinesin spindle protein (KSP).
For research use only. We do not sell to patients.
- Purity: 99.43%
- Formula: C30H28D5ClN4O2
- Molecular Weight:522.09
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Kinesin Isoforms
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Biological Activity
Description
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled CAS 336113-53-2
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Appearance Solid
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Molecular Weight 522.09
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Formula C30H28D5ClN4O2
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Color White to off-white
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SMILES
O=C1N(CC2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])C([C@@H](C(C)C)N(CCCN)C(C3=CC=C(C)C=C3)=O)=NC4=CC(Cl)=CC=C14
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Synonyms
SB-715992-d5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (191.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.9154 mL | 9.5769 mL | 19.1538 mL | 47.8845 mL |
| 5 mM | 0.3831 mL | 1.9154 mL | 3.8308 mL | 9.5769 mL | |
| 10 mM | 0.1915 mL | 0.9577 mL | 1.9154 mL | 4.7884 mL | |
| 15 mM | 0.1277 mL | 0.6385 mL | 1.2769 mL | 3.1923 mL | |
| 20 mM | 0.0958 mL | 0.4788 mL | 0.9577 mL | 2.3942 mL | |
| 25 mM | 0.0766 mL | 0.3831 mL | 0.7662 mL | 1.9154 mL | |
| 30 mM | 0.0638 mL | 0.3192 mL | 0.6385 mL | 1.5961 mL | |
| 40 mM | 0.0479 mL | 0.2394 mL | 0.4788 mL | 1.1971 mL | |
| 50 mM | 0.0383 mL | 0.1915 mL | 0.3831 mL | 0.9577 mL | |
| 60 mM | 0.0319 mL | 0.1596 mL | 0.3192 mL | 0.7981 mL | |
| 80 mM | 0.0239 mL | 0.1197 mL | 0.2394 mL | 0.5986 mL | |
| 100 mM | 0.0192 mL | 0.0958 mL | 0.1915 mL | 0.4788 mL |
Ispinesib-d5 Related Classifications
HY-50759S Related Classifications
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