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Cat. No.: HY-124790

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KSP-IA

KSP-IA (compound 17) is a potent kinesin spindle protein (KSP) inhibitor with an IC₅₀ value of 3.6 nM. KSP-IA inhibits cell mitosis.

For research use only. We do not sell to patients.

CAS No.: 639074-49-0
Formula: C₂₁H₂₂F₂N₂O
Molecular Weight:356.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

KSP-IA Chemical Structure

CAS No.: 639074-49-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

KSP-IA (compound 17) is a potent kinesin spindle protein (KSP) inhibitor with an IC₅₀ value of 3.6 nM. KSP-IA inhibits cell mitosis^[1].

All Kinesin Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	EC₅₀	12 nM Compound: 17	Mitotic arrest in A2780 cells Mitotic arrest in A2780 cells	[PMID: 16439123]
HEK293	IC₅₀	2400 nM Compound: 17	Inhibitory activity against human hERG receptor expressed in HEK cells Inhibitory activity against human hERG receptor expressed in HEK cells	[PMID: 16439123]

Chemical Information

CAS No. 639074-49-0
Molecular Weight 356.41
Formula C₂₁H₂₂F₂N₂O
SMILES

CC(C)[C@H](N)C(N1[C@H](C2=CC=CC=C2)C=C(C3=CC(F)=CC=C3F)C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Fraley ME, et, al. Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1775-9. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
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References

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KSP-IA

All Kinesin Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

KSP-IA Related Classifications

HY-124790 Related Classifications