SB-743921 free base
Based on 5 publication(s) in Google Scholar
SB-743921 free base is a potent selective inhibitor of the mitotic kinesin KSP (Eg5), with a Ki of 0.1 nM. SB-743921 free base can induce mitotic arrest, block cell cycle progression, induce apoptosis, and can be used in the research of myeloma, leukemia and other diseases.
For research use only. We do not sell to patients.
- CAS No.: 618430-39-0
- Formula: C31H33ClN2O3
- Molecular Weight:517.06
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) SB-743921 free base
MoreAll Kinesin Isoforms
More
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| BXPC-3 | GI50 |
25 nM
Compound: 2
|
Growth inhibition of human BxPC3 cells after 72 hrs by Alamar blue assay
Growth inhibition of human BxPC3 cells after 72 hrs by Alamar blue assay
|
[PMID: 23394180] |
| CHO | IC50 |
1.6 μM
Compound: 2
|
Inhibition of human ERG channel expressed in CHO cells by Ionworks HT assay
Inhibition of human ERG channel expressed in CHO cells by Ionworks HT assay
|
[PMID: 23394180] |
| HCT-116 | GI50 |
9.7 nM
Compound: 2
|
Growth inhibition of human HCT116 cells after 72 hrs by Alamar blue assay
Growth inhibition of human HCT116 cells after 72 hrs by Alamar blue assay
|
[PMID: 23394180] |
| K562 | GI50 |
1452 nM
Compound: 2
|
Growth inhibition of human K562 cells after 72 hrs by Alamar blue assay
Growth inhibition of human K562 cells after 72 hrs by Alamar blue assay
|
[PMID: 23394180] |
| LNCaP | GI50 |
15 nM
Compound: 2
|
Growth inhibition of human LNCAP cells after 72 hrs by Alamar blue assay
Growth inhibition of human LNCAP cells after 72 hrs by Alamar blue assay
|
[PMID: 23394180] |
| NCI-H1299 | GI50 |
35 nM
Compound: 2
|
Growth inhibition of human NCI-H1299 cells after 72 hrs by Alamar blue assay
Growth inhibition of human NCI-H1299 cells after 72 hrs by Alamar blue assay
|
[PMID: 23394180] |
| PC-3 | GI50 |
21.2 nM
Compound: 2
|
Growth inhibition of human PC3 cells after 72 hrs by Alamar blue assay
Growth inhibition of human PC3 cells after 72 hrs by Alamar blue assay
|
[PMID: 23394180] |
SB-743921 is a potent inhibitor of Eg5, with a Ki of 0.1 nM[1].
SB-743921 (1 nM) potently inhibits colony forming cell (CFC) formation of chronic myeloid leukemia (CML) primary cells, but exhibits slight inhibitory activities on the colony-forming ability of normal bone marrow progenitors[2].
SB-743921 (1-3 nM) induces apoptosis of CML primary CD34+ cells, and shows slight effect on normal CD34+ cells. SB-743921 in combination with imatinib displays additive anti-proliferative effect in KCL22 and CML CD34+ cells. Furthermore, SB-743921 overcomes imatinib resistance in CML cells[2].
SB-743921 (0.5 nM, 1 nM, 3 nM) inhibits MEK/ERK and AKT signaling in CML cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 618430-39-0
-
Molecular Weight 517.06
-
Formula C31H33ClN2O3
-
SMILES
O=C1C(CC2=CC=CC=C2)=C([C@@H](C(C)C)N(C(C3=CC=C(C)C=C3)=O)CCCN)OC4=CC(Cl)=CC=C41
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (5)
-
Journal Impact Factor
-
Most Recent
-
Cell Signal
KIF11 promotes AML progression, and its inhibition by SB-743921 suppresses disease advancement through mitotic G2/M phase arrest. [Abstract]2025 Nov:135:111980. PMID: 40659169 -
Cell Biol Int
ASPM promotes migration and invasion of anaplastic thyroid carcinoma by stabilizing KIF11. [Abstract]2023 Jul;47(7):1209-1221. PMID: 36883909 -
-
Gene
2025 Jul 5:955:149458. PMID: 40187619 -
Purity & Documentation
References
[2]. Yin Y, et al. Kinesin spindle protein inhibitor SB743921 induces mitotic arrest and apoptosis and overcomes imatinib resistance of chronic myeloid leukemia cells. Leuk Lymphoma. 2015 Jun;56(6):1813-20. [Content Brief]
[3]. Good JA, et al. Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models. J Med Chem. 2013 Mar 14;56(5):1878-93. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SB-743921 free base Related Classifications
HY-14661 Related Classifications
Powered by Bioz