Mal-PEG8-Val-Ala-PAB-SB-743921

Name: Mal-PEG8-Val-Ala-PAB-SB-743921
Brand: MedChemExpress
SKU: HY-149416
Rating: 4.5 (1 reviews)

Cat. No.: HY-149416 Purity: 99.28%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Mal-PEG8-Val-Ala-PAB-SB-743921 (Compound D7) is a Drug-Linker Conjugates for ADC. Mal-PEG8-Val-Ala-PAB-SB-743921 consists of KSP inhibitor SB-743921 (HY-14661) and a linker. Mal-PEG8-Val-Ala-PAB-SB-743921 can be used for synthesis of ADCs.

For research use only. We do not sell to patients.

Mal-PEG8-Val-Ala-PAB-SB-743921 Chemical Structure

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1411.03

Formula

C₇₃H₉₆ClN₇O₁₉

Appearance

Oil

Color

Colorless to light yellow

SMILES

O=C1C2=CC=C(Cl)C=C2OC([C@@H](C(C)C)N(C(C3=CC=C(C)C=C3)=O)CCCNC(OCC4=CC=C(NC([C@H](C)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN5C(C=CC5=O)=O)=O)=O)=O)=O)C=C4)=O)=C1CC6=CC=CC=C6

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (70.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7087 mL	3.5435 mL	7.0870 mL
5 mM	0.1417 mL	0.7087 mL	1.4174 mL
10 mM	0.0709 mL	0.3544 mL	0.7087 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.28%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (253 KB) HNMR (365 KB) RP-HPLC (235 KB) MS (70 KB)

Handling Instructions (2659 KB)

References

[1]. Li Y, et al. A novel antibody-KSP inhibitor conjugate improves KSP inhibitor efficacy in vitro and in vivo. Biomaterials. 2023 Jul 28;301:122258. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.7087 mL	3.5435 mL	7.0870 mL	17.7176 mL
	5 mM	0.1417 mL	0.7087 mL	1.4174 mL	3.5435 mL
	10 mM	0.0709 mL	0.3544 mL	0.7087 mL	1.7718 mL
	15 mM	0.0472 mL	0.2362 mL	0.4725 mL	1.1812 mL
	20 mM	0.0354 mL	0.1772 mL	0.3544 mL	0.8859 mL
	25 mM	0.0283 mL	0.1417 mL	0.2835 mL	0.7087 mL
	30 mM	0.0236 mL	0.1181 mL	0.2362 mL	0.5906 mL
	40 mM	0.0177 mL	0.0886 mL	0.1772 mL	0.4429 mL
	50 mM	0.0142 mL	0.0709 mL	0.1417 mL	0.3544 mL
	60 mM	0.0118 mL	0.0591 mL	0.1181 mL	0.2953 mL