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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
MAPKAPK2 (MK2)
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "MAPKAPK2 (MK2)" in MCE Product Catalog:
6
6 Publications Verification
Target:
Research Areas:
MK2-IN-3 is a potent and selective inhibitor of MAPKAP-K2 (MK-2), with an IC50 of 8.5 nM. MK2-IN-3 shows selectivity for MK-2 over MK-3, MK-5, ERK2, MNK1, p38a (IC50s=0.21, 0.081, 3.44, 5.7, and >100 μM, respectively) and MSK1, MSK2, CDK2, JNK2, IKK2 (IC50s>200 μM). MK2-IN-3 can reduce TNFα production in both U937 cells and in vivo .
6
6 Publications Verification
Target:
Research Areas:
MK2-IN-1 hydrochloride (compound 1) is a potent and selecitve MAPKAPK2 (MK2) inhibitor with an IC50 of 0.11 uM for MK2 and an EC50 of 0.35 uM for pHSP27. MK2-IN-1 hydrochloride impaires the phosphorylation level of serine residues in the Tfcp2l1 protein [2].
6
6 Publications Verification
Target:
Research Areas:
MK2-IN-1 (compound 1) is a potent and selecitve MAPKAPK2 (MK2) inhibitor with an IC50 of 0.11 uM for MK2 and an EC50 of 0.35 uM for pHSP27. MK2-IN-1 impaires the phosphorylation level of serine residues in the Tfcp2l1 protein [2].
6
6 Publications Verification
Target:
Research Areas:
MK2-IN-3 hydrate (compound 16) is an orally active, selective, and ATP-competitive MAPKAP-K2 (MK-2) inhibitor with an IC50 of 8.5 nM.MK2-IN-3 hydrate is exceptional selectivity against MK-3 (IC50=0.21 μM), MK-5 (IC50=0.081 μM), ERK2 (IC50=3.44 μM), MNK1(IC50=5.7 μM) as well as CDK2, JNK2, IKK2, MSK1, and MSK2 .
3
3 Cited Publications
Target:
Research Areas:
PF-3644022 is a potent, selective, orally active and ATP-competitive MAPKAPK2 (MK2) inhibitor with an IC50 of 5.2 nM and a Ki of 3 nM. PF-3644022 also inhibits MK3 and p38 regulated/activated kinase (PRAK) with IC50s of 53 nM and 5.0 nM, respectively. PF-3644022 potently inhibits TNFα production and has anti-inflammatory effect .
Cat. No.: HY-147283
CAS No.: 1105658-32-9
Target:
Research Areas:
MK2-IN-4 is a MAPKAPK2 (MK2) inhibitor with an IC50 value of 45 nM. MK2-IN-4 can be used in the research of cancer, inflammation, immunology .
Cat. No.: HY-P702662
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: MAPKAPK2; MAPKAP Kinase 2; MAPK Activated Protein Kinase 2; MAPKAP-K2; MK2; MK-2; Mitogen-Activated Protein Kinase-Activated Protein Kinase 2; MAPK-Activated Protein Kinase 2; MAP Kinase-Activated Protein Kinase 2; MAPKAPK-2
Species:
Human
Source:
E. coli
Cat. No.: HY-P705848
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPKAPK2; MAPKAP Kinase 2; MAPK Activated Protein Kinase 2; MAPKAP-K2; MK2; MK-2; Mitogen-Activated Protein Kinase-Activated Protein Kinase 2; MAPK-Activated Protein Kinase 2; MAP Kinase-Activated Protein Kinase 2; MAPKAPK-2
Species:
Human
Source:
E. coli
Cat. No.: HY-P706072
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: MAPKAPK2; MAPKAP Kinase 2; MAPK Activated Protein Kinase 2; MAPKAP-K2; MK2; MK-2; Mitogen-Activated Protein Kinase-Activated Protein Kinase 2; MAPK-Activated Protein Kinase 2; MAP Kinase-Activated Protein Kinase 2; MAPKAPK-2
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P701804
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPKAPK2; MAPKAP Kinase 2; MAPK Activated Protein Kinase 2; MAPKAP-K2; MK2; MK-2; Mitogen-Activated Protein Kinase-Activated Protein Kinase 2; MAPK-Activated Protein Kinase 2; MAP Kinase-Activated Protein Kinase 2; MAPKAPK-2
Species:
Human
Source:
E. coli
Cat. No.: HY-P701805
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPKAPK2; MAPKAP Kinase 2; MAPK Activated Protein Kinase 2; MAPKAP-K2; MK2; MK-2; Mitogen-Activated Protein Kinase-Activated Protein Kinase 2; MAPK-Activated Protein Kinase 2; MAP Kinase-Activated Protein Kinase 2; MAPKAPK-2
Species:
Human
Source:
E. coli
Cat. No.: HY-P80214
Synonyms: MAP kinase activated protein Kinase 2 antibody;
MAP kinase-activated protein kinase 2 antibody;
MAPK activated protein kinase 2 antibody;
MAPK-activated protein kinase 2 antibody;
MAPK2_HUMAN antibody;
MAPKAP K2 antibody;
MAPKAP kinase 2 antibody;
MAPKAPK 2 antibody;
MAPKAPK-2 antibody;
MAPKAPK2 antibody;
Mitogen activated protein kinase activated protein kinase 2 antibody;
MK 2 antibody;
MK2 antibody
Cat. No.: HY-P80214A
Synonyms: MAP kinase activated protein Kinase 2 antibody;
MAP kinase-activated protein kinase 2 antibody;
MAPK activated protein kinase 2 antibody;
MAPK-activated protein kinase 2 antibody;
MAPK2_HUMAN antibody;
MAPKAP K2 antibody;
MAPKAP kinase 2 antibody;
MAPKAPK 2 antibody;
MAPKAPK-2 antibody;
MAPKAPK2 antibody;
Mitogen activated protein kinase activated protein kinase 2 antibody;
MK 2 antibody;
MK2 antibody
Cat. No.: HY-182596
CAS No.: 1105659-16-2
Target:
Research Areas:
INHIB1X is a tetracyclic MAPKAP-K2 (MK2) inhibitor with an IC50 of 0.02 μM. INHIB1X inhibits LPS-induced TNFα release in human peripheral blood mononuclear cells (hPBMCs). INHIB1X suppresses the phosphorylation of hsp27 in Anisomycin-stimulated THP-1 cells. INHIB1X can be used for the research of inflammatory and tumor diseases .
Cat. No.: HY-107427R
CAS No.: 1276121-88-0
Research Areas:
PF-3644022 (Standard) is the analytical standard of PF-3644022 (HY-107427). This product is intended for research and analytical applications. PF-3644022 is a potent, selective, orally active and ATP-competitive MAPKAPK2 (MK2) inhibitor with an IC50 of 5.2 nM and a Ki of 3 nM. PF-3644022 also inhibits MK3 and p38 regulated/activated Kinase (PRAK) with IC50s of 53 nM and 5.0 nM, respectively. PF-3644022 potently inhibits TNFα production and has anti-inflammatory effect .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
