1. MAPK/ERK Pathway
  2. MAPKAPK2 (MK2)
  3. MK2-IN-1 hydrochloride

MK2-IN-1 hydrochloride 

Cat. No.: HY-12834A Purity: 99.19%
Handling Instructions

MK2-IN-1 hydrochloride is a potent and selecitve MAPKAPK2(MK2) inhibitor(IC50=0.11 uM) with a non-ATP competitive binding mode.

For research use only. We do not sell to patients.

MK2-IN-1 hydrochloride Chemical Structure

MK2-IN-1 hydrochloride Chemical Structure

CAS No. : 1314118-94-9

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10 mM * 1 mL in DMSO USD 73 In-stock
Estimated Time of Arrival: December 31
5 mg USD 65 In-stock
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10 mg USD 120 In-stock
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50 mg USD 480 In-stock
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100 mg USD 850 In-stock
Estimated Time of Arrival: December 31
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Description

MK2-IN-1 hydrochloride is a potent and selecitve MAPKAPK2(MK2) inhibitor(IC50=0.11 uM) with a non-ATP competitive binding mode. IC50 value: 0.11 uM [1] Target: MAPKAPK2(MK2) inhibitor MK2-IN-1 was profiled for kinase selectivity by screening against a broad panel of 150 protein kinases at a concentration of 10 μM, and only CK1γ3 was significantly inhibited at greater than 50%. MK2-IN-1 inhibited pro-inflammatory cytokine secretion from the human THP1 acute monocytic leukemia cell line, causing dose-dependent inhibition of LPS-stimulated TNFα and IL6 secretion. MK2-IN-1 also dose dependently inhibited IL1β-stimulated matrixmetalloprotease (MMP)13 secretion from the SW1353 chondrosarcoma cell line and human primary chondrocyte cultures. Of note, given its high degree of selectivity, our data suggest that MK2-IN-1 may be an excellent pharmacologic tool for specifically exploring and validating MK2 biology [3].

Molecular Weight

509.43

Formula

C₂₇H₂₆Cl₂N₄O₂

CAS No.

1314118-94-9

SMILES

O=C(C1=CC=C(C2=CC=C(Cl)C=C2)O1)N(C3=CC=C(N4CCNCC4)C=C3)CC5=NC=CC=C5.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (196.30 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9630 mL 9.8149 mL 19.6298 mL
5 mM 0.3926 mL 1.9630 mL 3.9260 mL
10 mM 0.1963 mL 0.9815 mL 1.9630 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.67 mg/mL (3.28 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.67 mg/mL (3.28 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.67 mg/mL (3.28 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.19%

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Keywords:

MK2-IN-1MAPKAPK2 (MK2)Mitogen-activated protein kinase activated protein kinase 2MAP kinase activated protein kinase 2MAPK activated protein kinase 2MAPKAP kinase 2Inhibitorinhibitorinhibit

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MK2-IN-1 hydrochloride
Cat. No.:
HY-12834A
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