1. MAPK/ERK Pathway Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  2. MAPKAPK2 (MK2) HSP
  3. MK2-IN-1

MK2-IN-1 (compound 1) is a potent and selecitve MAPKAPK2 (MK2) inhibitor with an IC50 of 0.11 uM for MK2 and an EC50 of 0.35 uM for pHSP27. MK2-IN-1 impaires the phosphorylation level of serine residues in the Tfcp2l1 protein.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (MK2-IN-1 hydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

MK2-IN-1 Chemical Structure

MK2-IN-1 Chemical Structure

CAS No. : 1314118-92-7

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Description

MK2-IN-1 (compound 1) is a potent and selecitve MAPKAPK2 (MK2) inhibitor with an IC50 of 0.11 uM for MK2 and an EC50 of 0.35 uM for pHSP27. MK2-IN-1 impaires the phosphorylation level of serine residues in the Tfcp2l1 protein[1][2].

In Vitro

MK2-IN-1 (purchased from MCE; 5 μM; 0.5-8 h) gradually increases Tfcp2l1 protein level without a change in the Tfcp2l1 transcript level within 2 h[2].
MK2-IN-1 induces more alkaline phosphatase (AP)-positive colonies than the other factors in a short time[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: 46C mouse embryonic stem cells (mESCs)
Concentration: 5 μM
Incubation Time: 0.5, 1, 2, 8 h
Result: The Tfcp2l1 protein level gradually increased without a change in the Tfcp2l1 transcript level within 2 h.
Molecular Weight

472.97

Formula

C27H25ClN4O2

CAS No.
SMILES

O=C(C1=CC=C(C2=CC=C(Cl)C=C2)O1)N(C3=CC=C(N4CCNCC4)C=C3)CC5=NC=CC=C5

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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MK2-IN-1
Cat. No.:
HY-12834
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