1. MAPK/ERK Pathway
  2. MAPKAPK2 (MK2)
  3. MK-2 Inhibitor III

MK-2 Inhibitor III 

Cat. No.: HY-112457 Purity: >99.0%
Handling Instructions

MK-2 Inhibitor III (compound 16) is an orally active, selective, and ATP-competitive MAPKAP-K2 (MK-2) inhibitor with an IC50 of 0.85 nM, and is exceptional selectivity against MK-3 (IC50=0.21 μM), MK-5 (IC50=0.081 μM), ERK2 (IC50=3.44 μM), MNK1(IC50=5.7 μM) as well as CDK2, JNK2, IKK2, MSK1, and MSK2.

For research use only. We do not sell to patients.

MK-2 Inhibitor III Chemical Structure

MK-2 Inhibitor III Chemical Structure

CAS No. : 1186648-22-5

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Description

MK-2 Inhibitor III (compound 16) is an orally active, selective, and ATP-competitive MAPKAP-K2 (MK-2) inhibitor with an IC50 of 0.85 nM, and is exceptional selectivity against MK-3 (IC50=0.21 μM), MK-5 (IC50=0.081 μM), ERK2 (IC50=3.44 μM), MNK1(IC50=5.7 μM) as well as CDK2, JNK2, IKK2, MSK1, and MSK2[1].

IC50 & Target

IC50: 0.85 nM (MK-2), 0.21 μM (MK-3), 0.081 μM (MK-5), 3.44 μM (ERK2), 5.7 μM (MNK1)[1]

In Vitro

MK-2 Inhibitor III suppresses TNFα production in U397 cells with an IC50 of 4.4 μM[1].

Molecular Weight

358.39

Formula

C₂₁H₁₈N₄O₂

CAS No.

1186648-22-5

SMILES

O=C1C2=C(NC(C3=CC(C4=CC5=CC=CC=C5N=C4)=NC=C3)=C2)CCN1.O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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MK-2 Inhibitor III
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HY-112457
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