PF-3644022 (Standard)

Cat. No.: HY-107427R: Data Sheet Handling Instructions
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PF-3644022 (Standard) is the analytical standard of PF-3644022 (HY-107427). This product is intended for research and analytical applications. PF-3644022 is a potent, selective, orally active and ATP-competitive MAPKAPK2 (MK2) inhibitor with an IC₅₀ of 5.2 nM and a K_i of 3 nM. PF-3644022 also inhibits MK3 and p38 regulated/activated K_inase (PRAK) with IC₅₀s of 53 nM and 5.0 nM, respectively. PF-3644022 potently inhibits TNFα production and has anti-inflammatory effect.

For research use only. We do not sell to patients.

PF-3644022 (Standard) Chemical Structure

CAS No. : 1276121-88-0

Size	Stock	Quantity
1 mg	Get quote 4 - 6 Weeks 3 - 5 Weeks 5 - 7 Weeks 4 - 6 weeks	Estimated Time of Arrival: December 31
5 mg	Get quote 4 - 6 Weeks 3 - 5 Weeks 5 - 7 Weeks 4 - 6 weeks	Estimated Time of Arrival: December 31
10 mg	Get quote 4 - 6 Weeks 3 - 5 Weeks 5 - 7 Weeks 4 - 6 weeks	Estimated Time of Arrival: December 31
25 mg	Get quote 4 - 6 Weeks 3 - 5 Weeks 5 - 7 Weeks 4 - 6 weeks	Estimated Time of Arrival: December 31
50 mg	Get quote 4 - 6 Weeks 3 - 5 Weeks 5 - 7 Weeks 4 - 6 weeks	Estimated Time of Arrival: December 31
100 mg	Get quote 4 - 6 Weeks 3 - 5 Weeks 5 - 7 Weeks 4 - 6 weeks	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

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Description	PF-3644022 (Standard) is the analytical standard of PF-3644022 (HY-107427). This product is intended for research and analytical applications. PF-3644022 is a potent, selective, orally active and ATP-competitive MAPKAPK2 (MK2) inhibitor with an IC₅₀ of 5.2 nM and a K_i of 3 nM. PF-3644022 also inhibits MK3 and p38 regulated/activated K_inase (PRAK) with IC₅₀s of 53 nM and 5.0 nM, respectively. PF-3644022 potently inhibits TNFα production and has anti-inflammatory effect^[1].
IC₅₀ & Target	IC50: 5.2 nM (MK2), 5.0 nM (PRAK) and 53 nM (MK3)^[1]. Ki: 3 nM (MK2)^[1]
Molecular Weight	374.46
Formula	C₂₁H₁₈N₄OS
CAS No.	1276121-88-0
SMILES	O=C1C2=C(NC[C@@H](C)N1)C3=C(C=CC4=NC(C5=CN=C(C)C=C5)=CC=C34)S2
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (268 KB) Handling Instructions (2659 KB)
References	[1]. Mourey RJ, et al. A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation. J Pharmacol Exp Ther. 2010 Jun;333(3):797-807 [Content Brief]