2. MAPK/ERK Pathway
  3. MAPKAPK2 (MK2)
  4. INHIB1X

INHIB1X is a tetracyclic MAPKAP-K2 (MK2) inhibitor with an IC50 of 0.02 μM. INHIB1X inhibits LPS-induced TNFα release in human peripheral blood mononuclear cells (hPBMCs). INHIB1X suppresses the phosphorylation of hsp27 in Anisomycin-stimulated THP-1 cells. INHIB1X can be used for the research of inflammatory and tumor diseases.

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INHIB1X

INHIB1X Chemical Structure

CAS No. : 1105659-16-2

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INHIB1X Related Antibodies

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Description

INHIB1X is a tetracyclic MAPKAP-K2 (MK2) inhibitor with an IC50 of 0.02 μM. INHIB1X inhibits LPS-induced TNFα release in human peripheral blood mononuclear cells (hPBMCs). INHIB1X suppresses the phosphorylation of hsp27 in Anisomycin-stimulated THP-1 cells. INHIB1X can be used for the research of inflammatory and tumor diseases[1].

In Vitro

INHIB1X (Compound 29) potently inhibits recombinant MK2 enzyme, with an IC50 of 0.02 μM[1].
INHIB1X inhibits LPS (HY-D1056)-induced TNFα release from hPBMCs, with an IC50 of 1.8 μM[1].
INHIB1X inhibits the phosphorylation of hsp27 in THP-1 cells stimulated by Anisomycin (HY-18982), with an IC50 of 1.3 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

INHIB1X Related Antibodies
Molecular Weight

388.44

Formula

C23H21FN4O
CAS No.
SMILES

O=C1NCC2(CN(C2)C)C3=C1C4=C(C5=CC(C6=C(F)C=CC=C6)=NC=C5CC4)N3
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Room temperature in continental US; may vary elsewhere.
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References
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INHIB1X Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

INHIB1X1105659-16-2MAPKAPK2 (MK2)Mitogen-activated protein kinase activated protein kinase 2MAP kinase activated protein kinase 2MAPK activated protein kinase 2MAPKAP kinase 2MAPKAP-K2 (MK2) inhibitorhPBMCsTHP-1 cellsinflammatorytumor diseasesInhibitorinhibitorinhibit

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