INHIB1X
INHIB1X is a tetracyclic MAPKAP-K2 (MK2) inhibitor with an IC50 of 0.02 μM. INHIB1X inhibits LPS-induced TNFα release in human peripheral blood mononuclear cells (hPBMCs). INHIB1X suppresses the phosphorylation of hsp27 in Anisomycin-stimulated THP-1 cells. INHIB1X can be used for the research of inflammatory and tumor diseases.
For research use only. We do not sell to patients.
- CAS No.: 1105659-16-2
- Formula: C23H21FN4O
- Molecular Weight:388.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| PBMC | IC50 |
0.1 μM
Compound: 16A
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Inhibition of LPS-induced TNFalpha production in human PBMC preincubated for 30 mins measured after 3 hrs of LPS stimulation
Inhibition of LPS-induced TNFalpha production in human PBMC preincubated for 30 mins measured after 3 hrs of LPS stimulation
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[PMID: 20591669] |
INHIB1X (Compound 29) potently inhibits recombinant MK2 enzyme, with an IC50 of 0.02 μM[1].
INHIB1X inhibits LPS (HY-D1056)-induced TNFα release from hPBMCs, with an IC50 of 1.8 μM[1].
INHIB1X inhibits the phosphorylation of hsp27 in THP-1 cells stimulated by Anisomycin (HY-18982), with an IC50 of 1.3 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1105659-16-2
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Molecular Weight 388.44
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Formula C23H21FN4O
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SMILES
O=C1NCC2(CN(C2)C)C3=C1C4=C(C5=CC(C6=C(F)C=CC=C6)=NC=C5CC4)N3
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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