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MCHR1 antagonist

" in MedChemExpress (MCE) Product Catalog:

By Targets:	MCHR1 (GPR24) (20) 5-HT Receptor (2) Cytochrome P450 (1) Potassium Channel (1) Reference Standards (1)
By Research Areas:	Cardiovascular Disease (1) Endocrinology (6) Metabolic Disease (14) Neurological Disease (6)

Targets Recommended: MCHR1 (GPR24)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-U00257

AZD1979	MCHR1 (GPR24)	Metabolic Disease Endocrinology
AZD1979 is a Melanin-concentrating hormone receptor 1 (MCHr1) antagonist with an IC₅₀ of ~12 nM.

HY-100318

MCHR1 antagonist 5	MCHR1 (GPR24)	Metabolic Disease
MCHR1 antagonist 5 (Compound 80) is a melanin-concentrating hormone receptor 1 (MCHR1) antagonist. MCHR1 antagonist 5 can be uesd for the study of a variety of metabolic, feeding and sexual disorders .

HY-107625A

SNAP 94847 hydrochloride 2 Publications Verification	MCHR1 (GPR24)	Neurological Disease
SNAP 94847 hydrochloride is a novel, high affinity selective melanin-concentrating hormonereceptor1 (MCHR1) antagonist with (K_i= 2.2 nM, K_d=530 pM), it displays >80-fold and >500-fold selectivity over MCHα1A and MCHD2 receptors respectively. SNAP 94847 hydrochloride binds with high affinity to the mouse and rat MCHR1 with minimal cross-reactivity to other GPCR, ion channels, enzymes, and transporters .

HY-100321

MCHR1 antagonist 2	MCHR1 (GPR24) Potassium Channel	Metabolic Disease Endocrinology
MCHR1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1, with an IC₅₀ of 65 nM; MCHR1 antagonist 2 also inhibits hERG, with an IC₅₀ of 4.0 nM in IMR-32 cells .

HY-12433

BMS-819881	MCHR1 (GPR24) Cytochrome P450	Metabolic Disease Endocrinology
BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a K_i of 7 nM. BMS-819881 also is selective and potent for CYP3A4 activity with an EC₅₀ of 13 μM.

HY-108049

GW856464	MCHR1 (GPR24)	Cardiovascular Disease Metabolic Disease
GW856464 is an antagonist for *MCHR1*. GW856464 can be studied in research for cardiovascular diseases and obesity .

HY-136152

MCHR1 antagonist 3	MCHR1 (GPR24)	Metabolic Disease Endocrinology
MCHR1 antagonist 3 is a potent the melanin-concentrating hormone receptor-1 (MCHR1) antagonist. MCHR1 antagonist 3 is used to regulate energy metabolism .

HY-161899

MCHR1 antagonist 4	MCHR1 (GPR24)	Others
MCHR1 antagonist 4 (Compound 2m) is a blood-brain barrier permeable *MCHR1* antagonist with K_i values of 0.74 nM and 0.76 nM for hMCHR1 and rMCHR1, respectively. MCHR1 antagonist 4 is also an effective anti-obesity agent .

HY-107626

ATC0065	MCHR1 (GPR24) 5-HT Receptor	Neurological Disease
ATC0065 is a potent, selective and orally active melanin-concentrating hormone (MCH) receptor 1 (MCHR1) antagonist with an IC₅₀ of 15.7 nM for human MCHR1. ATC0065 does not exhibits significant activity for MCHR2. ATC0065 has anxiolytic and antidepressant activities .

HY-U00353

MCHR1 antagonist 1	MCHR1 (GPR24)	Metabolic Disease Endocrinology
MCHR1 antagonist 1 is a selective antagonist of melanin concentrating hormone-1 (MCH1) receptor, with a K_b of 1 nM and a K_i of 4 nM at human MCH1, and may be used to reduce the body mass.

HY-119015

MCHR1 antagonist 6	MCHR1 (GPR24)	Metabolic Disease
MCHR1 antagonist 6 is a melanin-concentrating hormone receptor 1 (MCHR1) antagonist. MCHR1 antagonist 6 interacts with receptor residue D123 via its central basic group, and forms hydrogen bonds with receptor residue Q127 via its 2-amino-quinoline portion. MCHR1 antagonist 6 can be used for the research of obesity .

HY-107626A

ATC0065 free base	MCHR1 (GPR24) 5-HT Receptor	Neurological Disease
ATC0065 free base is a potent, selective and orally active melanin-concentrating hormone (MCH) receptor 1 (MCHR1) antagonist with an IC₅₀ of 15.7 nM for human MCHR1. ATC0065 free base does not exhibits significant activity for MCHR2. ATC0065 free base has anxiolytic and antidepressant activities .

HY-12433A

BMS-830216	MCHR1 (GPR24)	Metabolic Disease
BMS-830216 is an antagonist of *MCHR-1*. BMS-830216 is a phosphate ester prodrug. BMS-830216 can be studied in obesity-related research .

HY-107625

SNAP 94847	MCHR1 (GPR24)	Neurological Disease Endocrinology
SNAP 94847 is a novel, high affinity selective melanin-concentrating hormonereceptor1 (MCHR1) antagonist with (K_i= 2.2 nM, K_d=530 pM), it displays >80-fold and >500-fold selectivity over MCHα1A and MCHD2 receptors respectively. SNAP 94847 binds with high affinity to the mouse and rat MCHR1 with minimal cross-reactivity to other GPCR, ion channels, enzymes, and transporters .

HY-101699A

AMG-076	MCHR1 (GPR24)	Metabolic Disease
AMG-076 is an orally bioavailable and selective *MCHR1* antagonist. AMG-076 results in significant reduction in body weight gain in nonobese mice fed a high-fat diet and in high-fat diet-induced obese (DIO) mice .

HY-101699

AMG-076 free base	MCHR1 (GPR24)	Metabolic Disease
AMG-076 free base is an orally bioavailable and selective *MCHR1* antagonist. AMG-076 free base results in significant reduction in body weight gain in nonobese mice fed a high-fat diet and in high-fat diet-induced obese (DIO) mice .

HY-116031

ATC0175 free base	MCHR1 (GPR24)	Metabolic Disease
ATC0175 (free base) is a potent and selective antagonist of melanin-concentrating hormone receptor 1 (MCH-R1) with an IC₅₀ value of 3.4 nM, as well as good selectivity over the Y5 and the α_2A receptors. ATC0175 (free base) is promising for research of obesity .

HY-120847

BI 186908	MCHR1 (GPR24)	Neurological Disease Metabolic Disease
BI 186908 is a selective and orally active MCH receptor 1 antagonist with an IC₅₀ of 22 nM and a K_i of 14 nM. BI 186908 binds with comparably high affinity to the recombinant human, cynomolgus monkey (IC₅₀ of 18 nM), dog (IC₅₀ of 23 nM) and rat (IC₅₀ of 18 nM) MCH-R1. BI 186908 can significantly reduce the body weight of diet-induced obese rats. BI 186908 can be used for the study of obesity .

HY-107625AR

SNAP 94847 hydrochloride (Standard)	Reference Standards MCHR1 (GPR24)	Neurological Disease
SNAP 94847 hydrochloride (Standard) is the analytical standard of SNAP 94847 (hydrochloride) (HY-107625A). This product is intended for research and analytical applications. SNAP 94847 hydrochloride is a novel, high affinity selective melanin-concentrating hormonereceptor1 (MCHR1) antagonist with (K_i= 2.2 nM, K_d=530 pM), it displays >80-fold and >500-fold selectivity over MCHα1A and MCHD2 receptors respectively. SNAP 94847 hydrochloride binds with high affinity to the mouse and rat MCHR1 with minimal cross-reactivity to other GPCR, ion channels, enzymes, and transporters .

HY-185478

NGD-4715	MCHR1 (GPR24)	Metabolic Disease
NGD-4715 is an orally effective melanin-concentrating hormone receptor 1 (MCHR1) antagonist with IC₅₀ and K_i values of 10.6 nM and 5.9 nM, respectively. NGD-4715 acts as an inhibitor of food intake, a body weight regulator and a metabolic regulator, and reduces food intake, body weight gain and blood glucose levels in diet-induced obese rats. NGD-4715 is applicable to obesity-related research .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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MCHR1 antagonist

Inhibitors & Agonists