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Cat. No.: HY-119015

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MCHR1 antagonist 6

MCHR1 antagonist 6 is a melanin-concentrating hormone receptor 1 (MCHR1) antagonist. MCHR1 antagonist 6 interacts with receptor residue D123 via its central basic group, and forms hydrogen bonds with receptor residue Q127 via its 2-amino-quinoline portion. MCHR1 antagonist 6 can be used for the research of obesity.

For research use only. We do not sell to patients.

CAS No.: 645399-82-2
Formula: C₁₉H₂₃N₃OS
Molecular Weight:341.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

MCHR1 antagonist 6 Chemical Structure

CAS No.: 645399-82-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
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References
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Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	0.015 μM Compound: 7	Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cells Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cells	[PMID: 17532215]

In Vitro

MCHR1 antagonist 6 (Compound 7) potently inhibits ¹²⁵I-MCH binding to h-MCH-R1 expressed in HEK293 cells with an IC₅₀ of 15 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 645399-82-2
Molecular Weight 341.47
Formula C₁₉H₂₃N₃OS
SMILES

N=1C(=CC(=C2C=C(OC)C=CC12)C)NCCCNCC3=CSC=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Giordanetto F, et al. Discovery of cyclopentane- and cyclohexane-trans-1,3-diamines as potent melanin-concentrating hormone receptor 1 antagonists. Bioorg Med Chem Lett. 2007;17(15):4232-4241. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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