BI 186908
BI 186908 is a selective and orally active MCH receptor 1 antagonist with an IC50 of 22 nM and a Ki of 14 nM. BI 186908 binds with comparably high affinity to the recombinant human, cynomolgus monkey (IC50 of 18 nM), dog (IC50 of 23 nM) and rat (IC50 of 18 nM) MCH-R1. BI 186908 can significantly reduce the body weight of diet-induced obese rats. BI 186908 can be used for the study of obesity.
For research use only. We do not sell to patients.
- CAS No.: 1453500-36-1
- Formula: C23H26N4O4
- Molecular Weight:422.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| U-937 | IC50 |
506 μM
Compound: 11g, BI 186908
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Cytotoxicity against human U937 cells
Cytotoxicity against human U937 cells
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[PMID: 26105194] |
Ki: 14 nM (MCH receptor 1)
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1453500-36-1
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Molecular Weight 422.48
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Formula C23H26N4O4
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SMILES
O=C1C=C(OCC2=NC=C(OC)C=C2)C=NN1CC(C3=CC=C(CN(C)C)C=C3C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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