1453500-36-1
Chemical Structure
BI 186908
- CAS No.: 1453500-36-1
- Formula:C23H26N4O4
- Molecular Weight:422.48
IUPAC Name: 2-(2-(4-((dimethylamino)methyl)-2-methylphenyl)-2-oxoethyl)-5-((5-methoxypyridin-2-yl)methoxy)pyridazin-3(2H)-one
InChIKey: ACBKFGPDANWBLT-UHFFFAOYSA-N
SMILES: O=C1C=C(OCC2=NC=C(OC)C=C2)C=NN1CC(C3=CC=C(CN(C)C)C=C3C)=O
Biological Activity: BI 186908 is a selective and orally active MCH receptor 1 antagonist with an IC50 of 22 nM and a Ki of 14 nM. BI 186908 binds with comparably high affinity to the recombinant human, cynomolgus monkey (IC50 of 18 nM), dog (IC50 of 23 nM) and rat (IC50 of 18 nM) MCH-R1. BI 186908 can significantly reduce the body weight of diet-induced obese rats. BI 186908 can be used for the study of obesity[1].
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BI 186908 | BI 186908 is a selective and orally active MCH receptor 1 antagonist with an IC50 of 22 nM and a Ki of 14 nM. BI 186908 binds with comparably high affinity to the recombinant human, cynomolgus monkey (IC50 of 18 nM), dog (IC50 of 23 nM) and rat (IC50 of 18 nM) MCH-R1. BI 186908 can significantly reduce the body weight of diet-induced obese rats. BI 186908 can be used for the study of obesity. | |||||||||||||||||||||
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