2. GPCR/G Protein Neuronal Signaling
  3. MCHR1 (GPR24)
  4. NGD-4715

NGD-4715 is an orally effective melanin-concentrating hormone receptor 1 (MCHR1) antagonist with IC50 and Ki values of 10.6 nM and 5.9 nM, respectively. NGD-4715 acts as an inhibitor of food intake, a body weight regulator and a metabolic regulator, and reduces food intake, body weight gain and blood glucose levels in diet-induced obese rats. NGD-4715 is applicable to obesity-related research.

For research use only. We do not sell to patients.

NGD-4715

NGD-4715 Chemical Structure

CAS No. : 873318-96-8

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NGD-4715 Related Antibodies

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Description

NGD-4715 is an orally effective melanin-concentrating hormone receptor 1 (MCHR1) antagonist with IC50 and Ki values of 10.6 nM and 5.9 nM, respectively. NGD-4715 acts as an inhibitor of food intake, a body weight regulator and a metabolic regulator, and reduces food intake, body weight gain and blood glucose levels in diet-induced obese rats. NGD-4715 is applicable to obesity-related research[1].

In Vitro

NGD-4715 potently inhibits MCHR, with extremely weak inhibitory activity against hERG channels (IC50 = 38.4 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NGD-4715 Related Antibodies
Parmacokinetics
Species Dose Route T1/2 CL Vss Tmax Cmax F AUC0-∞
Rat[1] 10 mg/kg p.o. 2.1 h 27.7 mL/min/kg 2.8 L/kg 0.5 h 212 ng/mL 40.0 % 765 ng·h/mL
In Vivo

NGD-4715 (5-15 mg/kg; p.o.; twice daily; 10-26 days) dose-dependently reduces food intake and body weight in diet-induced obese Wistar rats that are prone to obesity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (male, obesity-prone, diet-induced obesity model)[1]
Dosage: 5 mg/kg (10-day treatment); 5 mg/kg (26-day treatment); 15 mg/kg (26-day treatment)
Administration: p.o.; twice daily; 10 days; 26 days
Result: Caused a 3.1% reduction in body weight over 10 days.
Reduced weight gain relative to controls over 26 days at 5 mg/kg twice daily.
Induced body weight loss over 26 days at 15 mg/kg twice daily.
Dose-dependently reduced daily food intake.
Lowered blood glucose levels, improved glucose tolerance, and reduced diet-induced hyperinsulinemia and hyperleptinemia.
Prevented post-treatment hyperphagia, with body weight gain paralleling vehicle controls during recovery.
Showed no signs of malaise, altered locomotor activity, or anxiogenic effects.
Molecular Weight

477.52

Formula

C25H30F3N3O3
CAS No.
SMILES

CC1=C(C=CC(OCCO)=C1C)[C@@H]2N3[C@](CCC2)([H])CN(CC3)C(C4=CN=C(C(F)(F)F)C=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NGD-4715 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NGD-4715873318-96-8NGD4715NGD 4715MCHR1 (GPR24)Melanin concentrating hormone receptor 1metabolic modulatormelanin-concentrating hormone receptor 1Wistar ratshyperinsulinemiadiet-induced obesity ratshyperleptinemiabody weight modulatorfood intake inhibitorMCHR1hERG channelInhibitorinhibitorinhibit

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