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NRP1 Human Pre-designed siRNA Set A contains three designed siRNAs for NRP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Tubulin/NRP1-IN-1 (compound TN-2) is a dual inhibitor of Tubulin and NRP1 with IC50s of 0.71 and 0.85 μM, respectively. Tubulin/NRP1-IN-1 significantly inhibits the viability of prostate tumor cell lines and induces apoptosis[1].
EG01377 is a potent, bioavailable and selective inhibitor of neuropilin-1(NRP1), with a Kd of 1.32 μM, and IC50s of both 609 nM for NRP1-a1 and NRP1-b1. EG01377 has antiangiogenic, antimigratory, and antitumor effects [1].
EG01377 dihydrochloride is a potent, bioavailable and selective inhibitor of neuropilin-1(NRP1), with a Kd of 1.32 μM, and IC50s of 609 nM for both NRP1-a1 and NRP1-b1. EG01377 dihydrochloride has antiangiogenic, antimigratory, and antitumor effects [1].
Vesencumab (MNRP-1685A) is IG1 antibody against neuropilin-1(NRP-1). Vesencumab binds to NRP-1 and prevents the subsequent coupling of NRP-1 to VEGFR-2. Vesencumab has anti-angiogenic and anti-neoplastic activities. Vesencumab can be used in the research of metastatic solid tumors, including ovarian cancer [1] .
EG00229 is a neuropilin 1 (NRP1) receptor antagonist. EG00229 selectively inhibits VEGF-A binding to NRP1 b1 domain with an IC50 of 3 μM, but has no effect on VEGFA binding to VEGFR-1 and VEGFR-2 [1].
ATWLPPR Peptide TFA, a heptapeptide, acts as a selective neuropilin-1 inhibitor, inhibits VEGF165 binding to NRP-1, used in the research of angiogenesis [1]. ATWLPPR Peptide TFA has potential in reducing the early retinal damage caused by diabetes .
Certepetide (CEND-1) is a bifunctional cyclic peptide (a.k.a. iRGD). Certepetide is a tumor-penetrating enhancer via RGD motif interaction with alphav-integrins and via activating NRP-1, and transforms the solid tumor microenvironment into a temporary agent conduit. Certepetide accumulates in tumors, and is used in the research of pancreatic cancer and other solid tumors [1] .
Certepetide (CEND-1) is a bifunctional cyclic peptide (a.k.a. iRGD). Certepetide is a tumor-penetrating enhancer via RGD motif interaction with alphav-integrins and via activating NRP-1, and transforms the solid tumor microenvironment into a temporary agent conduit. Certepetide accumulates in tumors, and is used in the research of pancreatic cancer and other solid tumors [1] .
Vesencumab (MNRP-1685A) is IG1 antibody against neuropilin-1(NRP-1). Vesencumab binds to NRP-1 and prevents the subsequent coupling of NRP-1 to VEGFR-2. Vesencumab has anti-angiogenic and anti-neoplastic activities. Vesencumab can be used in the research of metastatic solid tumors, including ovarian cancer [1] .
Neuropilin-1 protein plays an important role by binding to VEGF-165, possibly inhibiting its cellular binding and inducing apoptosis. This dual function suggests its role in regulating VEGF-mediated processes. Neuropilin-1 Protein, Human (HEK293, Fc) is the recombinant human-derived Neuropilin-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Neuropilin-1 Protein, Human (HEK293, Fc) is 623 a.a., with molecular weight of 116-130 kDa.
Neuropilin-1 protein plays an important role by binding to VEGF-165, possibly inhibiting its cellular binding and inducing apoptosis. This dual function suggests its role in regulating VEGF-mediated processes. Neuropilin-1 Protein, Human (619a.a, HEK293, C-His) is the recombinant human-derived Neuropilin-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Neuropilin-1 Protein, Human (619a.a, HEK293, C-His) is 623 a.a., with molecular weight of approximately 86.92 kDa.
Neuropilin-1 Protein plays a significant role by binding to VEGF-165, potentially inhibiting its cellular binding and inducing apoptosis. This dual functionality suggests its role in regulating VEGF-mediated processes. Interactions with semaphorin family members highlight its versatile ligand-binding capability. Neuropilin-1's expression adversely affects blood vessel number and integrity, suggesting a potential role in angiogenesis. Its diverse interactions underscore its importance in orchestrating complex cellular processes and implications in angiogenesis and apoptotic pathways. Neuropilin-1 Protein, Human (644a.a, HEK293, C-His) is the recombinant human-derived Neuropilin-1 protein, expressed by HEK293, with C-6*His labeled tag. The total length of Neuropilin-1 Protein, Human (644a.a, HEK293, C-His) is 644 a.a., with molecular weight of ~90 kDa.
Neuropilin-1 (NRP1) is one of two neuropilins which acts as a cell-surface receptor which is involved in the development of the cardiovascular system, angiogenesis, the formation of certain neuronal circuits, organogenesis outside the nervous system, cellular internalization and vascular leakage as well as mediates the chemorepulsant activity of semaphorins. NRP1 also binds many ligands and various types of co-receptors to affect cell survival, migration, and attraction. Neuropilin-1 Protein, Human (644a.a, HEK293, His) is the recombinant human-derived Neuropilin-1 protein, expressed by HEK293 , with C-His, C-6*His labeled tag. The total length of Neuropilin-1 Protein, Human (644a.a, HEK293, His) is 623 a.a., with molecular weight of ~90 kDa.
Neuropilin-1 Protein plays a significant role by binding to VEGF-165, potentially inhibiting its cellular binding and inducing apoptosis. This dual functionality suggests its role in regulating VEGF-mediated processes. Interactions with semaphorin family members highlight its versatile ligand-binding capability. Neuropilin-1's expression adversely affects blood vessel number and integrity, suggesting a potential role in angiogenesis. Its diverse interactions underscore its importance in orchestrating complex cellular processes and implications in angiogenesis and apoptotic pathways. Neuropilin-1 Protein, Human (V179A, HEK293, Fc) is the recombinant human-derived Neuropilin-1 protein, expressed by HEK293 , with C-hFc labeled tag and V179A mutation. The total length of Neuropilin-1 Protein, Human (V179A, HEK293, Fc) is 623 a.a., with molecular weight of ~107.4 kDa.
Neuropilin-1 Protein plays a significant role by binding to VEGF-165, potentially inhibiting its cellular binding and inducing apoptosis. This dual functionality suggests its role in regulating VEGF-mediated processes. Interactions with semaphorin family members highlight its versatile ligand-binding capability. Neuropilin-1's expression adversely affects blood vessel number and integrity, suggesting a potential role in angiogenesis. Its diverse interactions underscore its importance in orchestrating complex cellular processes and implications in angiogenesis and apoptotic pathways. Neuropilin-1 Protein, Human (Biotinylated, HEK293, His-Avi, solution) is the recombinant human-derived Neuropilin-1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag and V179A mutation. The total length of Neuropilin-1 Protein, Human (Biotinylated, HEK293, His-Avi, solution) is 623 a.a., with molecular weight of ~73.1 kDa.
Neuropilin-1 Protein, a transmembrane glycoprotein, regulates axon guidance, angiogenesis, neuronal development, and immune responses. Neuropilin-1 can interacts with VEGF and semaphorins, and promote the growth, survival, and self-renewal of tumors. Neuropilin-1 also acts as an entry factor and potentiate SARS-CoV-2 and Epstein-Barr virus (EBV) infectivity. Furthermore, Neuropilin-1 acts as a co-receptor for TGF-β, and enhances TGF-β activity via the SMAD2/3 signaling pathway. Neuropilin-1 Protein, Cynomolgus (592a.a, HEK293, His) is the recombinant cynomolgus-derived Neuropilin-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Neuropilin-1 Protein, Cynomolgus (592a.a, HEK293, His) is 592 a.a., with molecular weight of 80-100 kDa.
Neuropilin-1 protein is an important receptor critical for cardiovascular system development, angiogenesis, neuronal circuit formation, and non-nervous system organogenesis. It mediates the chemical pulse activity of signaling proteins, recognizes C-terminal regular motifs on ligands, and promotes cellular internalization and vascular leakage. Neuropilin-1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Neuropilin-1 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of Neuropilin-1 Protein, Mouse (HEK293, Fc) is 856 a.a., with molecular weight of ~120 kDa.
Neuropilin-1 protein is an important receptor critical for cardiovascular system development, angiogenesis, neuronal circuit formation, and non-nervous system organogenesis. It mediates the chemical pulse activity of signaling proteins, recognizes C-terminal regular motifs on ligands, and promotes cellular internalization and vascular leakage. Neuropilin-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Neuropilin-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Neuropilin-1 Protein, Mouse (HEK293, His) is 835 a.a., with molecular weight of 100-120 kDa.
Neuropilin-1 protein plays an important role by binding to VEGF-165, possibly inhibiting its cellular binding and inducing apoptosis. This dual function suggests its role in regulating VEGF-mediated processes. Neuropilin-1 Protein, Human (HEK293, His) is the recombinant human-derived Neuropilin-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Neuropilin-1 Protein, Human (HEK293, His) is 623 a.a., with molecular weight of 85-100 kDa.
Neuropilin-1 protein plays an important role by binding to VEGF-165, possibly inhibiting its cellular binding and inducing apoptosis. This dual function suggests its role in regulating VEGF-mediated processes. Neuropilin-1 Protein, Human (Biotinylated, HEK293, Avi-His) is the recombinant human-derived Neuropilin-1 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. The total length of Neuropilin-1 Protein, Human (Biotinylated, HEK293, Avi-His) is 623 a.a., with molecular weight of 85-100 kDa.
