Vesencumab
Based on 1 Customer Validation
Vesencumab (MNRP-1685A) is IG1 antibody against neuropilin-1 (NRP-1). Vesencumab binds to NRP-1 and prevents the subsequent coupling of NRP-1 to VEGFR-2. Vesencumab has anti-angiogenic and anti-neoplastic activities. Vesencumab can be used in the research of metastatic solid tumors, including ovarian cancer.
For research use only. We do not sell to patients.
- Purity: 99.34%
- CAS No.: 1205533-60-3
- Molecular Weight:145.262 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
Description
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
NRP1/VEGF165R/CD34
In Vitro
Vesencumab (50 μg/mL, 6 days) inhibits the MAPK signaling pathway by inhibiting the activation of EGFR and PDGFRα, thereby inhibiting the spheroid formation of tumor cells of SUM159 and Hs578T[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SUM159, MDA-MB-231 and Hs578T
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Concentration:50 μg/mL
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Incubation Time:60 min
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Result:Inhibited pEGFR.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mouse SUM159 orthotopic xenograft models[3]
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Dosage:10 mg/kg
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Administration:ip, twice a week for 7 weeks
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Result:Inhibited tumor volume and weight.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG1 kappa
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized Neuropilin-1 Protein, Human (His) can bind Vesencumab. The EC50 for this effect is 5.571 ng/mL. -
Loaded Vesencumab on AHC2 biosensor, can bind Glycoprotein/G Protein, HRSV (95% Homology, HEK293, His, HY-P75814) with an affinity constant of 1.372E-09 M as determined in BLI assay. -
Flow Cytometry analysis of Hela cells labelling NRP1/VEGF165R/CD34 (red) with Vesencumab (anti-NRP1/VEGF165R/CD34) (HY-P99386). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.
Chemical Information
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CAS No. 1205533-60-3
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Appearance Liquid
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Molecular Weight 145.262 kDa
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Color Colorless to light yellow
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SMILES
[Vesencumab]
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Synonyms
MNRP-1685A
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)