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ATWLPPR Peptide TFA 

Cat. No.: HY-P1663A Purity: 98.99%
Handling Instructions

ATWLPPR Peptide TFA, a heptapeptide, acts as a selective neuropilin-1 inhibitor, inhibits VEGF165 binding to NRP-1, used in the research of angiogenesis. ATWLPPR Peptide TFA has potential in reducing the early retinal damage caused by diabetes.

For research use only. We do not sell to patients.

ATWLPPR Peptide TFA Chemical Structure

ATWLPPR Peptide TFA Chemical Structure

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 1259 In-stock
Estimated Time of Arrival: December 31
1 mg USD 120 In-stock
Estimated Time of Arrival: December 31
5 mg   Get quote  
10 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

ATWLPPR Peptide TFA, a heptapeptide, acts as a selective neuropilin-1 inhibitor, inhibits VEGF165 binding to NRP-1, used in the research of angiogenesis[1]. ATWLPPR Peptide TFA has potential in reducing the early retinal damage caused by diabetes[2].

IC50 & Target

Neuropilin-1[2]

In Vitro

ATWLPPR Peptide TFA is a selective neuropilin-1 inhibitor, inhibits VEGF165 binding to NRP-1 by 82% at 100 μM[1].

In Vivo

ATWLPPR (400 μg/kg, s.c.) preserves vascular integrity and decreases the oxidative stress level, possibly reduces the early retinal damage caused by diabetes[2].
ATWLPPR prevents the increase of inflammation-associated proteins (GFAP, VEGF and ICAM-1) in the retina[2].

References
Molecular Weight

954.00

Formula

C₄₂H₆₂F₃N₁₁O₁₁

SMILES

O=C(N[[email protected]@H]([[email protected]](O)C)C(N[[email protected]@H](CC1=CNC2=CC=CC=C12)C(N[[email protected]@H](CC(C)C)C(N3[[email protected]@H](CCC3)C(N4[[email protected]@H](CCC4)C(N[[email protected]@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)[[email protected]](C)N.OC(C(F)(F)F)=O

Storage
Protect from light
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
ATWLPPR Peptide TFA
Cat. No.:
HY-P1663A
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ATWLPPR Peptide TFA

Cat. No.: HY-P1663A