2. Immunology/Inflammation
  3. Complement System
  4. EG01377

EG01377 is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1), with a Kd of 1.32 μM, and IC50s of both 609 nM for NRP1-a1 and NRP1-b1. EG01377 has antiangiogenic, antimigratory, and antitumor effects.

For research use only. We do not sell to patients.

EG01377 Chemical Structure

EG01377 Chemical Structure

CAS No. : 2227996-00-9

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of EG01377:

Other Forms of EG01377:

EG01377 Related Antibodies

Top Publications Citing Use of Products

    EG01377 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2023 Feb 25;14(2):159.  [Abstract]

    EG01377 (20, 40, 80 µM; 14 days) significantly attenuates clone formation ability of PC-3 and DU-145 cells in a concentration-dependent manner.

    EG01377 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2023 Feb 25;14(2):159.  [Abstract]

    EG01377 (20, 40, 80 µM) attenuates the phosphorylation of EGFR, AKT, GSK3β, and mTOR in PC-3 and DU-145 cells.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    EG01377 is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1), with a Kd of 1.32 μM, and IC50s of both 609 nM for NRP1-a1 and NRP1-b1. EG01377 has antiangiogenic, antimigratory, and antitumor effects[1].

    IC50 & Target

    IC50: 609 nM (NRP1-a1 and NRP1-b)[1] Kd: 1.32 μM (NRP1-b1)[1]
    In Vitro

    EG01377 (3-30 μM; 30 minutes) inhibits vascular endothelial growth factor A (VEGF-A) stimulated tyrosine phosphorylation of VEGF-R2/KDR[1].
    EG01377 (30 μM) is able to significantly reduce HUVEC cell migration in response to VEGFA[1].
    EG01377 (30 μM; 5 days) can delay the VEGF-induced wound closure[1].
    EG01377 (30 μM) reduces network area, length, and branching points[1].
    EG01377 (30 μM; 7 days) reduces VEGF-induced angiogenesis[1].
    EG01377 (30 μM; 7 days) in combination with VEGFA reduces A375P (malignant melanoma) spheroid outgrowth[1].
    EG01377 (500 nM; 2 hours) blocks the production of transforming growth factor beta (TGFβ) by Nrp1+ regulatory T-cell SMAD3/AKT (Tregs) in the presence of tumor cell-derived factors[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    EG01377 Related Antibodies

    Western Blot Analysis[1]

    Cell Line: Human umbilical vein endothelial cells (HUVECs)
    Concentration: 3, 10, 30 μM
    Incubation Time: 30 minutes
    Result: Inhibited VEGF-A stimulated tyrosine phosphorylation of VEGF-R2/KDR with an IC50 of 30 μM.
    In Vivo

    EG01377 (2 mg/kg; i.v.) exhibits an encouraging half-life of 4.29 h, sufficient to sustain once per day dosing in mice[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: 6–8 week-old BABL/c female mice[1]
    Dosage: 2 mg/kg (Pharmacokinetic Analysis)
    Administration: I.v. administration
    Result: The half time (T1/2) of 4.29 h.
    Molecular Weight

    586.68

    Formula

    C26H30N6O6S2
    CAS No.
    SMILES

    O=S(C1=CC(C2=CC=C(CN)C=C2)=CC3=C1OCC3)(NC4=C(C(N[C@@H](CCC/N=C(N)/N)C(O)=O)=O)SC=C4)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    EG01377 Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    EG013772227996-00-9EG 01377EG-01377Complement Systemneuropilin-1NRP1NRP1-a1NRP1-b1antiangiogenicantimigratoryantitumorInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Salutation

    Applicant Name *

    		 

    Email Address *

    Phone Number *

    		 

    Organization Name *

    Department *

    		 

    Requested quantity *

    Country or Region *

    		      

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    EG01377
    Cat. No.:
    HY-112151
    Quantity:
    MCE Japan Authorized Agent:

    Customer Review

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Lot #

    Applicant Name *

    		 

    Email Address *

    Phone Number

    		 

    Department *

    Organization Name *

    		 

    Country or Region *

    Remarks

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.